0000950170-24-055832 | 10-Q | XBRL Viewer

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CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares shares in Thousands	Mar. 31, 2024	Dec. 31, 2023
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	230	230
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	200,000	200,000
Common stock, shares issued	62,797	63,307
Common stock, shares outstanding	62,797	63,307
Treasury stock, shares	32,005	32,005

Goodwill and Intangible Assets

3 Months Ended

Mar. 31, 2024

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill and Intangible Assets

7. Goodwill and Intangible Assets

Goodwill and intangible assets acquired are recognized at fair value as of the acquisition date. We recognized goodwill of $11.5 million and $6.4 million from our acquisitions of Entasis and La Jolla, respectively, in 2022. The carrying amount of goodwill

as of March 31, 2024 and December 31, 2023 was $17.9 million. We have not recognized any impairment losses related to goodwill during the periods presented.

Intangible assets with definite lives are amortized over their estimated useful lives. The carrying basis and accumulated amortization of recognized intangible assets as of March 31, 2024 and December 31, 2023 were as follows:


	March 31, 2024
	Useful Life	Gross		Accumulated			Net Carrying
(In thousands)	(Years)	Amount		Amortization			Amount
Marketed products	8-10	$	219,700	$	(30,763	)	$	188,937
In-process research and development			2,600		—		$	2,600
Collaboration agreement	10		35,400		(3,042	)	$	32,358
Total		$	257,700	$	(33,805	)	$	223,895


	December 31, 2023
	Useful Life	Gross		Accumulated			Net Carrying
(In thousands)	(Years)	Amount		Amortization			Amount
Marketed products	8-10	$	219,700	$	(25,204	)	$	194,496
In-process research and development			2,600		—			2,600
Collaboration agreement	10		35,400		(2,161	)		33,239
Total		$	257,700	$	(27,365	)	$	230,335

Intangible assets recognized as a result of the acquisition of Entasis amounted to $106.7 million, which consisted of Entasis’ in-process research and development related to its antibacterial therapeutic product candidates and a collaboration agreement amounting to $71.3 million and $35.4 million, respectively. Following the FDA approval of XACDURO® in May 2023, we started amortizing $68.7 million of the then in-process research and development as a marketed product, as well as the collaboration agreement, over their estimated useful lives. The useful life of the remaining in-process research and development of $2.6 million will be determined upon commercialization of the underlying product candidate; thus, no amortization expense for this intangible asset was recognized for the periods presented.

Intangible assets recognized as a result of the acquisition of La Jolla amounting to $151.0 million pertain to product rights and developed technologies on La Jolla’s currently marketed products. These are intangible assets with determinable lives and are amortized over their estimated useful lives.

We recognized amortization expense of $6.4 million and $3.8 million for the three months ended March 31, 2024 and 2023, respectively. Future amortization expense is expected to be $19.4 million for the remainder of 2024, $25.8 million for each of the years from 2025 to 2028 and $98.7 million thereafter.

Stock-Based Compensation - Summary of weighted-average assumptions used to calculate estimated value of stock options (Details) - Stock options - Innoviva [Member] - $ / shares	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Weighted-average
Valuation Assumptions
Dividend yield	0.00%	0.00%
Minimum
Valuation Assumptions
Risk-free interest rate	4.10%	3.70%
Expected term (in years)	5 years 10 months 24 days	5 years 1 month 28 days
Volatility	36.70%	38.10%
Weighted-average estimated fair value of stock options granted	$ 4.97	$ 5.4
Maximum
Valuation Assumptions
Risk-free interest rate	4.30%	4.00%
Expected term (in years)	6 years 1 month 24 days	6 years 1 month 9 days
Volatility	36.80%	38.50%
Weighted-average estimated fair value of stock options granted	$ 6.93	$ 5.42

Commitments and Contingencies

3 Months Ended

Mar. 31, 2024

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

12. Commitments and Contingencies

Operating Lease

We have operating leases for our corporate headquarters, office spaces and laboratory facilities.

The components of lease cost are as follows:


	Three months ended March 31,
(In thousands)	2024		2023
Straight line operating lease costs	$	317	$	357
Variable lease costs		4		48
Total lease costs	$	321	$	405

Supplemental cash flow information related to leases are as follows:


	Three months ended March 31,
(In thousands)	2024		2023
Cash paid for amounts included in the measurement of operating lease liabilities:	$	320	$	389

As of March 31, 2024, our operating leases have weighted-average remaining term of approximately 2.1 years and the weighted average discount rate on our operating lease liabilities was 7.5%.

Future minimum payments on our operating leases as of March 31, 2024 were as follows:


(In thousands)	March 31, 2024
Years ending December 31:
Remainder of 2024	$	1,052
2025		1,428
2026		143
2027		149
Total undiscounted lease payments		2,772
Less: imputed interest		(200	)
Total operating lease liabilities	$	2,572

Legal Proceedings

From time to time, the Company is involved in legal proceedings in the ordinary course of its business. We are not currently a party to any material legal proceedings except as discussed below.

On February 15, 2022, La Jolla received a paragraph IV notice of certification (the “First Notice Letter”) from Gland Pharma Limited (“Gland”) advising that Gland had submitted an Abbreviated New Drug Application (“ANDA”) to the FDA seeking approval to manufacture, use or sell a generic version of GIAPREZA® in the U.S. prior to the expiration of U.S. Patent Nos.: 9,220,745; 9,572,856; 9,867,863; 10,028,995; 10,335,451; 10,493,124; 10,500,247; 10,548,943; 11,096,983; and 11,219,662 (the “GIAPREZA® Patents”), which are listed in the FDA’s Approved Drug Products with Therapeutic Equivalence Evaluations (the “Orange Book”). The First Notice Letter alleges that the GIAPREZA® Patents are invalid, unenforceable and/or will not be infringed by the commercial manufacture, use or sale of the generic product described in Gland’s ANDA.

On March 29, 2022, La Jolla filed a complaint for patent infringement of the GIAPREZA® Patents against Gland and certain related entities in the United States District Court for the District of New Jersey in response to Gland’s ANDA filing. In accordance with the Hatch-Waxman Act, because GIAPREZA® is a new chemical entity and La Jolla filed a complaint for patent infringement within 45 days of receipt of the First Notice Letter, the FDA cannot approve Gland’s ANDA any earlier than 7.5 years from the approval of the GIAPREZA® NDA unless the District Court finds that all of the asserted claims of the patents-in-suit are invalid, unenforceable and/or not infringed.

On February 22, 2023, La Jolla received a paragraph IV notice of certification (the “Second Notice Letter”) from Gland advising that Gland had amended its ANDA filing to include a paragraph IV certification alleging that all claims of the newly-issued and Orange Book-listed U.S. Patent No. 11,559,559 (the “’559 Patent”), which covers GIAPREZA®, are invalid, unenforceable and/or not infringed.

On March 22, 2023, La Jolla filed a First Amended Complaint in this litigation adding Gland’s marketing and distribution partners for its ANDA angiotensin II product, Fresenius Kabi USA LLC and Fresenius Kabi SwissBiosim GmbH (collectively, the “Fresenius Kabi Defendants”), as co-defendants. On April 7, 2023, La Jolla filed a Second Amended Complaint in response to the Second Notice Letter, adding claims that the manufacture, use, sale, offer for sale, or import of Gland’s ANDA angiotensin II product will infringe the ’559 Patent. On November 14, 2023, La Jolla filed a Third Amended Complaint adding additional infringement claims against the Fresenius Kabi Defendants. We intend to vigorously enforce our intellectual property rights relating to GIAPREZA®.

Fact discovery closed on March 31, 2024 and expert discovery will be complete by August 2, 2024. A trial date has not yet been set in this matter.

Given the early stage of this matter, we cannot reasonably estimate a potential future loss or a range of potential future losses, if any, and have not recorded a contingent liability accrual as of March 31, 2024.

Indemnification

In the ordinary course of business, we may provide indemnifications of varying scope and terms to vendors, directors, officers, and other parties with respect to certain matters, including, but not limited to, losses arising out of breach of such agreements, services to be provided by us, our negligence or willful misconduct, violations of law, or intellectual property infringement claims made by third parties. In addition, we have entered into indemnification agreements with directors and certain officers and employees that will require us, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors, officers, or employees. No material demands have been made upon us to provide indemnification under such agreements, and thus, there are no claims that we are aware of that could have a material effect on our unaudited condensed consolidated financial statements. We also maintain director and officer insurance, which may cover certain liabilities arising from our obligation to indemnify our directors. To date, we have not incurred any material costs and have not accrued any material liabilities in the condensed consolidated financial statements as a result of these provisions.

Debt - Debt Maturities (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Long-term debt maturities for years ending December 31:
Remainder of 2024	$ 0
2025	192,500
2026	0
2027	0
2028	261,000
Total	$ 453,500	$ 453,500

Balance Sheet Components - Schedule of Other Accrued Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Balance Sheet Related Disclosures [Abstract]
Accrued contract manufacturing expenses	$ 2,197	$ 1,966
Accrued clinical and research expenses	554	776
Accrued professional services	$ 10,936	$ 8,876
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Other Liabilities, Current	Other Liabilities, Current
Current portion of lease liabilities	$ 1,268	$ 1,207
Royalty obligation payable	2,531	1,928
Accrued license fees and royalties	1,136	1,575
Other	5,125	3,370
Total other accrued liabilities	$ 23,747	$ 19,698

Stockholders' Equity (Additional Information) (Details) - Common stock - USD ($) $ / shares in Units, $ in Millions	1 Months Ended	3 Months Ended
	Apr. 25, 2024	Mar. 31, 2024	Oct. 31, 2022
Amount of shares repurchased			$ 100.0
Stock repurchased and retired during period, shares		634,107
Shares repurchased average price per share		$ 15.24
Stock repurchased and retired during period, value		$ 9.7
Subsequent Event
Stock repurchased and retired during period, shares	352,821
Shares repurchased average price per share	$ 14.91
Stock repurchased and retired during period, value	$ 5.3

Commitments and Contingencies - Schedule of Components of Lease Cost (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Lease, Cost [Abstract]
Straight line operating lease costs	$ 317	$ 357
Variable lease costs	4	48
Total lease costs	$ 321	$ 405

Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2024

Share-Based Payment Arrangement [Abstract]

Schedule of stock-based compensation expense

The following table summarizes stock-based compensation expense:


	Three Months Ended March 31,
(In thousands)	2024		2023
Selling, general and administrative	$	1,358	$	1,152
Research and development		97		446
Total	$	1,455	$	1,598

Summary of weighted-average assumptions used to calculate estimated value of stock options

Black-Scholes-Merton assumptions used in calculating the estimated value of stock options granted by Innoviva on the date of grant were as follows:


	Three Months Ended March 31,
	2024	2023
Risk-free interest rate	4.1% - 4.3%	3.7% - 4.0%
Expected term (in years)	5.90 - 6.15	5.16 - 6.11
Volatility	36.7% - 36.8%	38.1% - 38.5%
Dividend yield	0.0%	0.0%

Weighted-average estimated fair value of stock options granted	$4.97 - $6.93	$5.40 - $5.42

Debt - Schedule of Debt (Details) - USD ($) $ in Thousands	3 Months Ended
Debt - Schedule of Debt (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Debt
Total	$ 453,500		$ 453,500
Less: Unamortized debt discount and issuance costs	(6,741)		(7,266)
Total long-term debt, net	$ 446,759		446,234
HealthCare Royalty Partners
Debt
Maximum potential royalty payout	14.00%
Increase in maximum potential payout percent	18.00%
Maximum aggregate royalty payments	$ 225,000
Required payment for breach of agreement, payment one	125,000
Payment for royalty agreement	20,000
2025 Notes \| Convertible senior notes
Debt
Total debt	192,500		192,500
Less: Unamortized debt discount and issuance costs	(1,024)		(1,205)
2028 Notes \| Convertible senior notes
Debt
Total debt	261,000		261,000
Less: Unamortized debt discount and issuance costs	(5,717)		(6,061)
Royalty Financing Agreement \| Loans Payable [Member] \| HealthCare Royalty Partners
Debt
Interest expense	2,700	$ 1,200
Deferred Royalty Obligations	70,100		$ 69,900
Royalty Payments	$ 1,900
Interest Rate of Deferred Royalty Obligation	16.62%

Revenue Recognition - Schedule of net revenue from collaboration arrangement (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Revenue Recognition and Collaboration Arrangements
Total net royalty revenue	$ 77,499	$ 76,372
Royalty revenue
Revenue Recognition and Collaboration Arrangements
Total net royalty revenue	58,415	56,858
GSK
Revenue Recognition and Collaboration Arrangements
Total net royalty revenue	58,415	56,858
GSK \| Royalty revenue
Revenue Recognition and Collaboration Arrangements
Royalties	61,871	60,314
Less: amortization of capitalized fees paid to a related party	(3,456)	(3,456)
GSK \| RELVAR/BREO
Revenue Recognition and Collaboration Arrangements
Royalties	52,138	50,883
GSK \| ANORO
Revenue Recognition and Collaboration Arrangements
Royalties	$ 9,733	$ 9,431

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References + Details

- Definition

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 924
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 11.L)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479941/924-10-S99-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 5
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-5

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 30
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-30

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 42
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-42

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 22
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-22

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 32
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-32

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 40
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-40

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 22
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-22

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 32
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-32

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 41
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482810/280-10-50-41

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 4
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-4

+ Details

Net Income Per Share - Basic and Diluted EPS (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Numerator:
Net income, basic	$ 36,532	$ 34,865
Net income, diluted	$ 39,054	$ 37,574
Denominator:
Weighted-average shares used to compute basic net income per share	63,185	67,786
Dilutive effect of options and awards granted under equity incentive plan and employee stock purchase plan	240	139
Weighted-average shares used to compute diluted net income per share	84,531	89,788
Net income per share
Basic net income per share	$ 0.58	$ 0.51
Net income per share: diluted	$ 0.46	$ 0.42
2023 Notes
Numerator:
Add: interest expense on Notes, net of tax effect	$ 0	$ 81
Denominator:
Dilutive effect	0	757
2025 Notes
Numerator:
Add: interest expense on Notes, net of tax effect	$ 1,121	$ 1,169
Denominator:
Dilutive effect	11,150	11,150
2028 Notes
Numerator:
Add: interest expense on Notes, net of tax effect	$ 1,401	$ 1,459
Denominator:
Dilutive effect	9,956	9,956

Consolidated Entities (Details) - USD ($) $ in Thousands		3 Months Ended		12 Months Ended
Consolidated Entities (Details) - USD ($) $ in Thousands	Mar. 30, 2022	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023	May 31, 2021	Dec. 31, 2020
CONSOLIDATED ENTITIES
Initial contribution				$ 190,000
Total assets		$ 1,267,612		1,243,507
Net investment-related income (expense) earned (incurred)		$ 200
ISP Fund LP
CONSOLIDATED ENTITIES
Distribution from partnership					$ 110,000
Economic interest of the Partnership (in percent)		100.00%
Total assets		$ 287,200		311,800
Total liabilities		1,800		$ 100
Changes in fair values of equity and long-term investments, net		$ 26,200	$ 4,100
Net investment-related income (expense) earned (incurred)			$ 500
Capital contribution	$ 110,000					$ 300,000
Lock-up period	36 months

Debt

3 Months Ended

Mar. 31, 2024

Debt Disclosure [Abstract]

Debt

11. Debt

Our debt consists of the following:


	March 31,			December 31,
(In thousands)	2024			2023
2025 Notes	$	192,500		$	192,500
2028 Notes		261,000			261,000
Total debt		453,500			453,500
Less: Unamortized debt discount and issuance costs		(6,741	)		(7,266	)
Total long-term debt, net	$	446,759		$	446,234

Convertible Subordinated Notes Due 2023

In January 2013, we completed an underwritten public offering of $287.5 million aggregate principal amount of our 2023 Notes, which matured on January 15, 2023.

The remaining balance of $96.2 million was fully paid upon the maturity date.

Convertible Senior Notes Due 2025

On August 7, 2017, we completed a private placement of $192.5 million aggregate principal amount of our 2025 Notes. The proceeds include the 2025 Notes sold pursuant to the $17.5 million over-allotment option granted by us to the initial purchasers, which option was exercised in full. The 2025 Notes were sold in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act. The 2025 Notes are senior unsecured obligations and bear interest at a rate of 2.5% per year, payable semi-annually in arrears on February 15 and August 15 of each year, beginning on February 15, 2018.

The 2025 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. The initial conversion rate for the 2025 Notes is 57.9240 shares of our common stock per $1,000 principal amount of the 2025 Notes (which is equivalent to an initial conversion price of approximately $17.26 per share), representing a 30.0% conversion premium over the last reported sale price of the Company’s common stock on August 1, 2017, which was $13.28 per share. The conversion rate is subject to customary anti-dilution adjustments in certain circumstances. The 2025 Notes will mature on August 15, 2025, unless repurchased or converted in accordance with their terms prior to such date. Prior to February 15, 2025, the 2025 Notes will be convertible at the option of the holders only upon the occurrence of specified events and during certain periods, as described below. From, and including, February 15, 2025, until the close of business on the second scheduled trading day immediately preceding the maturity date, the 2025 Notes will be convertible at any time.

Holders of the 2025 Notes may convert all or a portion of their 2025 Notes prior to the close of business on February 15, 2025 only under the following circumstances:

•

after September 30, 2017, if our closing common stock price for at least 20 days out of the most recent 30 consecutive trading days of the preceding quarter is greater than 130% of the current conversion price of the 2025 Notes;

•

for five consecutive business days, if the average trading price per $1,000 of Notes during the prior 10 consecutive trading days is less than 98% of the product of our closing common stock price and the conversion rate of the 2025 Notes on such day; and,

•

upon the occurrence of specified corporate events, including certain distributions, the occurrence of a fundamental changes (as defined in the indenture governing the 2025 Notes) or a transaction resulting in our common stock converting into other securities or property or assets.

On or after February 15, 2025, holders of the 2025 Notes may convert their 2025 Notes at any time until the close of business on the second scheduled trading day immediately preceding the maturity date of the 2025 Notes.

In the event of default or a fundamental change (as defined above), holders of the 2025 Notes may require us to repurchase all or a portion of their 2025 Notes at price equal to 100% of the principal amount of the 2025 Notes, plus any accrued and unpaid interest.

The annual effective interest rate on the 2025 Notes is 2.88%.

Our outstanding 2025 Notes balances consisted of the following:


	March 31,			December 31,
(In thousands)	2024			2023
Principal	$	192,500		$	192,500
Debt discount and issuance costs, net		(1,024	)		(1,205	)
Net carrying amount	$	191,476		$	191,295

The following table sets forth total interest expense recognized related to the 2025 Notes for the three months ended March 31, 2024 and 2023:


	Three Months Ended March 31,
(In thousands)	2024		2023
Contractual interest expense	$	1,203	$	1,203
Amortization of debt issuance costs		181		176
Total interest and amortization expense	$	1,384	$	1,379

Convertible Senior Notes Due 2028

In March 2022, we completed a private placement of $261.0 million aggregate principal amount of our 2028 Notes, which will mature on March 15, 2028. The proceeds include the 2028 Notes sold pursuant to the $45.0 million over-allotment option granted by us to the initial purchasers, of which $36.0 million was exercised. The 2028 Notes were sold in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act.

The net proceeds from the sale of the $261.0 million aggregate principal amount of 2028 Notes were approximately $252.6 million after deducting the initial purchasers’ discounts and commissions and our estimated offering expenses. We used approximately $21.0 million of the net proceeds from the offering to fund the cost of entering into the capped call transactions described below. In addition, we used $165.6 million of the remaining net proceeds to repurchase $144.8 million aggregate principal amount of the 2023 Notes in separate and individually negotiated transactions with certain holders of the 2023 Notes, which closed concurrently with the issuance of the 2028 Notes. We expect to use the remaining net proceeds for general corporate purposes.

The 2028 Notes bear interest at an annual rate of 2.125% that is payable semi-annually in arrears in cash on March 15 and September 15 of each year, beginning on September 15, 2022.

The 2028 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. The initial conversion rate was 38.1432 shares per $1,000 principal amount of the 2028 Notes, subject to customary anti-dilution adjustment in certain circumstances, which represented an initial conversion price of approximately $26.22 per share.

Prior to September 15, 2027, the 2028 Notes will be convertible at the option of the holders only upon the occurrence of specified events and during certain periods, and will be convertible on or after September 15, 2027, at any time until the close of business on the second scheduled trading day immediately preceding the maturity date of the 2028 Notes.

Holders of the 2028 Notes may convert all or a portion of their 2028 Notes prior to the close of business on September 15, 2027, only under the following circumstances:

•

after March 31, 2022, if our closing common stock price for at least 20 days out of the most recent 30 consecutive trading days of the preceding quarter is greater than 130% of the current conversion price of the 2028 Notes;

•

upon the occurrence of specified corporate events, including certain distributions, the occurrence of a fundamental changes (as defined in the indenture governing the 2028 Notes) or a transaction resulting in our common stock converting into other securities or property or assets.

On or after September 15, 2027, holders of the 2028 Notes may convert their 2028 Notes at any time until the close of the business on the second day immediately preceding the maturity date of the 2028 Notes.

The 2028 Notes will be redeemable, in whole or in part, at our option at any time, and from time to time, on or after March 20, 2025, and on or before the 75th scheduled trading day immediately before the maturity date but only if the last reported sale price per share of our common stock exceeds 130% of the conversion price for a specified period of time. The redemption price will be equal to the principal amount of the 2028 Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date. In addition, calling any 2028 Note for redemption will constitute a make-whole fundamental change (as defined in the indenture governing the 2028 Notes) with respect to that 2028 Note, in which case the conversion rate applicable to the conversion of that 2028 Note will be increased in certain circumstances if it is converted after it is called for redemption.

If we undergo a fundamental change, subject to certain conditions, holders may require us to purchase for cash all or any portion of their 2028 Notes. The fundamental change purchase price will be 100% of the principal amount of the 2028 Notes to be purchased plus any accrued and unpaid interest to, but excluding, the fundamental change purchase date.

The indenture governing the 2028 Notes contains customary terms and covenants, including a merger covenant and that upon certain events of default occurring and continuing, either the Trustee or the holders of at least 25% of the aggregate principal amount of the outstanding Notes may declare 100% of the principal of, and accrued and unpaid interest, if any, on, all the Notes to be due and payable immediately.

In connection with the offering of the 2028 Notes, we entered into privately negotiated capped call transactions. The cap price of the capped call transaction is initially $33.9850 per share and is subject to certain adjustments under the terms of the capped call transactions. The capped call transactions cover, subject to customary adjustments, the number of shares of common stock initially underlying the 2028 Notes. The capped call transactions are expected generally to reduce potential dilution to our common stock upon conversion of the 2028 Notes or at our election (subject to certain conditions) offset any cash payments we are required to make in excess of the aggregate principal amount of converted 2028 Notes, as the case may be, with such reduction or offset subject to a cap.

The annual effective interest rate on the 2028 Notes is 2.70%.

Our outstanding 2028 Notes balance consisted of the following:


	March 31,			December 31,
(In thousands)	2024			2023
Principal	$	261,000		$	261,000
Debt issuance costs, net		(5,717	)		(6,061	)
Net carrying amount	$	255,283		$	254,939

The following table sets forth total interest expense recognized related to the 2028 Notes for the three months ended March 31, 2024 and 2023:


	Three months ended March 31,
(In thousands)	2024		2023
Contractual interest expense	$	1,387	$	1,387
Amortization of debt issuance costs		344		335
Total interest and amortization expense	$	1,731	$	1,722

Debt Maturities

The aggregate scheduled maturities of our convertible debt as of March 31, 2024 were as follows:


(In thousands)	March 31, 2024
Years ending December 31:
Remainder of 2024	$	—
2025		192,500
2026		—
2027		—
2028		261,000
Total	$	453,500

Deferred Royalty Obligation

As part of our acquisition of La Jolla, we recorded the fair value of its deferred royalty obligation in connection with La Jolla’s royalty financing agreement (“La Jolla Royalty Agreement”) with HealthCare Royalty Partners (“HCR”). Under the terms of the La Jolla Royalty Agreement, HCR is entitled to receive quarterly royalties on worldwide net sales of GIAPREZA® until either January 1, 2031 or when the maximum aggregate royalty payments have been made, whichever occurs first. Quarterly payments to HCR under the Royalty Agreement start at a maximum royalty rate, with step-downs based on the achievement of annual net product sales thresholds. The maximum royalty rate through December 31, 2013 was 14%. Starting January 1, 2024, the maximum royalty rate was increased to 18% based on the terms of the agreement. The La Jolla Royalty Agreement is subject to maximum aggregate royalty payments to HCR of $225.0 million.

For the three months ended March 31, 2024 and 2023, we recognized interest expense of $2.7 million and $1.2 million, respectively. The carrying value of the deferred royalty obligation as of March 31, 2024 and December 31, 2023 was $70.1 million and $69.9 million, respectively (refer to Note 8 “Balance Sheet Components”). During the three months ended March 31, 2024, we made royalty payments to HCR of $1.9 million. The deferred royalty obligation was valued using Level 3 inputs, and its carrying value as of March 31, 2024 approximates fair value. The fair value of the deferred royalty obligation was calculated as the discounted deferred royalty obligations based on risk-adjusted revenue projections for GIAPREZA®. The annual effective interest rate of the deferred royalty obligation for the current period is 16.62%.

Under the terms of the La Jolla Royalty Agreement, if we are unable to meet certain obligations, including the obligation to use commercially reasonable and diligent efforts to commercialize GIAPREZA®, HCR would have the right to terminate the La Jolla Royalty Agreement and demand payment of either $125.0 million or $225.0 million (depending on which obligation we have failed to meet) less aggregate royalties already paid to HCR. As of March 31, 2024, inclusive of the aggregate royalties paid to HCR by La Jolla under the La Jolla Royalty Agreement prior to our acquisition, La Jolla paid $20.0 million of aggregate royalties to HCR. In the event that we fail to pay such amount if and when due in a timely manner, HCR would have the right to foreclose on the GIAPREZA®-related assets. HCR has no recourse against any asset other than GIAPREZA®.

Certain contract provisions within the La Jolla Royalty Agreement that could result in an acceleration of amounts due under the La Jolla Royalty Agreement are recognized as embedded derivatives that require bifurcation from the deferred royalty obligation and fair value recognition. We determined the fair value of each derivative by assessing the probability of each event occurring, as well as the potential repayment amounts and timing of such repayments that would result under various scenarios. As a result of this assessment, we determined that the fair value of the embedded derivatives is immaterial and, therefore, not recognized as of March 31, 2024 and December 31, 2023. We estimate the fair value of the embedded derivatives for each reporting period until either the features lapse or the La Jolla Royalty Agreement is terminated, whichever occurs first. Any material change in the fair value of the embedded derivatives will be recorded as either a gain or loss in the unaudited condensed consolidated statements of income.

- Definition

The entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1B
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1B

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(c))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 470
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//470/tableOfContent

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1B
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1B

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Name Accounting Standards Codification
-Section 50
-Paragraph 1B
-Subparagraph (g)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1B

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Name Accounting Standards Codification
-Section 50
-Paragraph 1B
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1B

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 1C
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1C

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Name Accounting Standards Codification
-Section 50
-Paragraph 1C
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1C

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Name Accounting Standards Codification
-Section 50
-Paragraph 1E
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1E

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1I

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1I

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1I
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481139/470-20-50-1I

+ Details

Commitments and Contingencies - Schedule of Supplemental Cash Flow Information Related to Leases (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Commitments and Contingencies Disclosure [Abstract]
Cash paid for amounts included in the measurement of operating lease liabilities:	$ 320	$ 389

CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Revenue:
Total revenue	$ 77,499	$ 76,372
Expenses:
Selling, general and administrative	30,405	19,735
Research and development	3,878	12,588
Amortization of acquired intangible assets	6,440	3,805
Changes in fair values of equity method investments, net	(35,342)	(15,817)
Changes in fair values of equity and long-term investments, net	13,335	2,164
Interest and dividend income	(4,399)	(3,365)
Interest expense	5,851	4,427
Other expense, net	1,236	1,346
Total expenses, net	32,375	35,232
Income before income taxes	45,124	41,140
Income tax expense, net	8,592	6,275
Net income and comprehensive income	$ 36,532	$ 34,865
Net income per share:
Basic	$ 0.58	$ 0.51
Diluted	$ 0.46	$ 0.42
Shares used to compute net income per share:
Basic	63,185	67,786
Diluted	84,531	89,788
Royalty revenue
Revenue:
Total revenue	$ 58,415	$ 56,858
Net product sales
Revenue:
Total revenue	19,084	11,514
Expenses:
Cost of products sold (inclusive of amortization of inventory fair value adjustments, excluding amortization of intangible assets)	10,971	8,749
License revenue
Revenue:
Total revenue	0	8,000
License
Expenses:
Cost of license revenue	$ 0	$ 1,600

Equity and Other Investments and Fair Value Measurements - Equity Investment in Armata (Details) - Armata $ / shares in Units, $ in Millions					3 Months Ended
	Mar. 04, 2024 USD ($)	Jul. 10, 2023 USD ($)	Jan. 10, 2023 USD ($)	Feb. 09, 2022 USD ($) $ / shares shares	Mar. 31, 2024 USD ($) Director Tranche	Mar. 31, 2023 USD ($)	Dec. 31, 2021 USD ($) shares	Mar. 31, 2021 USD ($) shares	Mar. 31, 2020 USD ($) shares	Jan. 01, 2024 $ / shares	Dec. 31, 2023 USD ($)
Equity Investment
Number of tranches \| Tranche					2
Percentage of maximum voting rights				49.50%	49.50%
Number of Investee's Board members currently representing the Company \| Director					3
Special terms on re-designating board member to board of investee				In addition, as of February 9, 2022, Armata entered into an amended and restated investor rights agreement with the Company and ISO, pursuant to which for as long as the Company and ISO hold at least 12.5% of the outstanding shares of Armata’s common stock on a fully-diluted, the Company and ISO shall have the right to designate two directors to Armata’s board of directors, and for so long as the Company and ISO hold at least 8%, but less than 12.5%, of the outstanding shares of Armata’s common stock on a fully-diluted basis, the Company and ISO shall have the right to designate one director to Armata’s board of directors, subject to certain conditions and qualifications set forth in the amended and restated investor rights agreement.
July 2023 Credit and Security Agreement
Equity Investment
Term loan facility in aggregate amount		$ 25.0
Debt Instrument, annual interest rate		14.00%
Debt instrument maturity date		Jan. 10, 2025
March 2024 Credit and Security Agreement
Equity Investment
Term loan facility in aggregate amount	$ 35.0
Debt Instrument, annual interest rate	14.00%
Debt instrument maturity date	Jun. 04, 2025
Secured Convertible Credit Agreement
Equity Investment
Debt instrument, description			On January 10, 2023, we entered into a Secured Convertible Credit Agreement (the “Credit Agreement”) with Armata, under which we extended a one-year convertible note (the “Armata Convertible Note”) in an aggregate amount of $30.0 million at an interest rate of 8.0% per annum.
Debt instrument, term			1 year
Term loan facility in aggregate amount			$ 30.0
Debt Instrument, annual interest rate			8.00%
Consolidated Investees
Equity Investment
Equity method investment ownership percentage					69.40%						69.40%
Two Directors
Equity Investment
Armata outstanding shares percentage				12.50%
Common stock and warrants
Equity Investment
Amount of securities purchase agreement									$ 25.0
Unrealized gain					$ 35.3	$ 15.8
Warrants purchased in 2020
Equity Investment
Number of warrants purchased under the securities purchase agreement \| shares									8,710,800
Exercise price of warrants \| $ / shares										$ 2.87
Term of warrants										5 years
Warrants purchased in 2021
Equity Investment
Exercise price of warrants \| $ / shares										$ 3.25
Term of warrants										5 years
Warrants purchased in 2022
Equity Investment
Exercise price of warrants \| $ / shares										$ 5
Term of warrants										5 years
Warrants
Equity Investment
Equity and long-term investments at fair value					47.1						$ 35.3
Common stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares									8,710,800
Equity and long-term investments at fair value					104.8						81.2
Armata Convertible Note
Equity Investment
Equity and long-term investments at fair value					64.3						51.9
Unrealized gain					12.4	$ 2.8
Armata July 2023 Term Loan
Equity Investment
Equity and long-term investments at fair value					27.4						$ 27.0
Unrealized gain					0.4
Armata March 2024 Term Loan
Equity Investment
Equity and long-term investments at fair value					35.5
Unrealized gain					$ 0.5
Minimum [Member] \| One Director
Equity Investment
Armata outstanding shares percentage				8.00%
Maximum [Member] \| One Director
Equity Investment
Armata outstanding shares percentage				12.50%
Innoviva Strategic Opportunities, LLC \| Common stock and warrants
Equity Investment
Amount of securities purchase agreement				$ 45.0				$ 20.0
Innoviva Strategic Opportunities, LLC \| Warrants
Equity Investment
Number of warrants to be purchased under the securities purchase agreement \| shares				4,500,000				6,153,847
Exercise price of warrants \| $ / shares				$ 5
Innoviva Strategic Opportunities, LLC \| Common stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares				9,000,000
Number of shares to be purchased under the securities purchase agreement \| shares							1,212,122
Number of warrants to be purchased under the securities purchase agreement \| shares								6,153,847
Amount of securities purchase agreement							$ 4.0

Balance Sheet Components - Schedule of Inventory (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Inventory Disclosure [Abstract]
Raw materials	$ 9,525	$ 11,257
Work-in-process	20,196	15,670
Finished goods	7,716	13,810
Total inventory	$ 37,437	$ 40,737

Balance Sheet Components

3 Months Ended

Mar. 31, 2024

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

8. Balance Sheet Components

Inventory

Inventory consisted of the following:


	March 31,		December 31,
(in thousands)	2024		2023
Raw materials	$	9,525	$	11,257
Work-in-process		20,196		15,670
Finished goods		7,716		13,810
Total inventory	$	37,437	$	40,737

As of March 31, 2024 and December 31, 2023, total inventory included net fair value adjustments resulting from the acquisition of La Jolla of approximately $16.1 million and $23.0 million, respectively, which will be amortized and recognized as cost of products sold when sales occur in future periods. The fair value adjustments recorded as part of cost of products sold amounted to $6.8 million for the three months ended March 31, 2024 and 2023.

Other Accrued Liabilities

Other accrued liabilities consisted of the following:


	March 31,		December 31,
(in thousands)	2024		2023
Accrued contract manufacturing expenses	$	2,197	$	1,966
Accrued clinical and research expenses		554		776
Accrued professional services		10,936		8,876
Current portion of lease liabilities		1,268		1,207
Royalty obligation payable		2,531		1,928
Accrued license fees and royalties		1,136		1,575
Other		5,125		3,370
Total other accrued liabilities	$	23,747	$	19,698

Other Long-term Liabilities

Other long-term liabilities consisted of the following:


	March 31,		December 31,
(in thousands)	2024		2023
Long-term portion of deferred royalty obligation	$	70,057	$	69,876
Long-term portion of lease liabilities		1,304	$	1,635
Contingent value rights liability		325		359
Total other long-term liabilities	$	71,686	$	71,870

Consolidated Entities and Acquisitions - Theravance Respiratory Company, LLC (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Income statements
Total net revenue	$ 77,499	$ 76,372
Other income, net	(1,236)	(1,346)
Income tax expense, net	8,592	6,275
Net income and comprehensive income	36,532	34,865
Royalty revenue
Income statements
Total net revenue	$ 58,415	$ 56,858

- Definition

Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References + Details

- Definition

The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

+ References

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities
Net income	$ 36,532	$ 34,865
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income taxes	3,244	(812)
Amortization of capitalized fees and depreciation of property and equipment	3,510	3,479
Amortization of acquired intangible assets	6,440	3,805
Inventory fair value step-up adjustment included in cost of products sold	6,843	6,842
Stock-based compensation	1,455	1,598
Amortization of debt discount and issuance costs	525	523
Changes in fair values of equity method investments, net	(35,342)	(15,817)
Changes in fair values of equity and long-term investments, net	13,335	2,164
Accrued interest income added to long-term investments	0	(1,482)
Other non-cash items	(1,513)	(2,062)
Changes in operating assets and liabilities:
Accounts receivable	315	(6,089)
Receivables from collaboration arrangement	7,750	(5,642)
Inventory	(3,543)	(598)
Prepaid expenses	5,079	5,440
Other assets	633	518
Accounts payable	(5,827)	2,994
Accrued personnel-related expenses and other accrued liabilities	441	(565)
Accrued interest payable	(2,589)	(3,526)
Income tax payable	49	49
Deferred revenue	(290)	0
Net cash provided by operating activities	37,047	25,684
Cash flows from investing activities
Purchases of trading securities	(43,136)	0
Purchases of equity and long-term investments	0	(35,689)
Purchases of equity investments managed by ISP Fund LP	(8,756)	(3,891)
Sales of equity investments managed by ISP Fund LP	5,342	1,289
Purchase and sales of other investments managed by ISP Fund LP, net	3,414	2,602
Purchases of property and equipment	0	(33)
Sale of property and equipment	98	0
Net cash used in investing activities	(43,038)	(35,722)
Cash flows from financing activities
Repurchase of common stock	(9,569)	(40,735)
Repurchase of shares to satisfy tax withholding	(84)	(23)
Proceeds from issuances of common stock, net	488	0
Payment for repurchase of convertible subordinated notes due 2023	0	(96,204)
Net cash used in financing activities	(9,165)	(136,962)
Net decrease in cash and cash equivalents	(15,156)	(147,000)
Cash and cash equivalents at beginning of period	193,513	291,049
Cash and cash equivalents at end of period	178,357	144,049
Supplemental Disclosure of Cash Flow Information:
Cash paid for interest	5,179	6,202
Supplemental Disclosure of Non-cash Investing and Financing Activities:
Accrued interest income converted to long-term investments	$ 799	$ 0

Equity and Other Investments and Fair Value Measurements - Available-for-Sale Securities (Details) - USD ($)
$ in Thousands

Mar. 31, 2024

Dec. 31, 2023

Available-for-Sale Securities

Amortized Cost

$ 151,836

$ 170,706

Gross Unrealized Gains

Gross Unrealized Losses

Estimated Fair Value

151,836

170,706

Credit loss

Money market funds

Available-for-Sale Securities

Amortized Cost

151,836

^[1]

170,706

^[2]

Gross Unrealized Gains

^[1]

^[2]

Gross Unrealized Losses

^[1]

^[2]

Estimated Fair Value

$ 151,836

^[1]

$ 170,706

^[2]

[1]	Money market funds are included in cash and cash equivalents in the condensed consolidated balance sheets.
[2]	Money market funds are included in cash and cash equivalents in the condensed consolidated balance sheets

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Description of Operations and Summary of Significant Accounting Policies (Policies)	3 Months Ended
	Mar. 31, 2024
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Description of Operations	Description of Operations Innoviva, Inc. (and where context requires, together with its subsidiaries referred to as “Innoviva”, the “Company”, or “we” and other similar pronouns) is a company with a portfolio of royalties and innovative healthcare assets. Our royalty portfolio contains respiratory assets partnered with Glaxo Group Limited (“GSK”), including RELVAR®/BREO® ELLIPTA® (fluticasone furoate/vilanterol, “FF/VI”) and ANORO® ELLIPTA® (umeclidinium bromide/ vilanterol, “UMEC/VI”). Under the Long-Acting Beta2 Agonist (“LABA”) Collaboration Agreement, Innoviva is entitled to receive royalties from GSK on sales of RELVAR®/BREO® ELLIPTA® as follows: 15% on the first $3.0 billion of annual global net sales and 5% for all annual global net sales above $3.0 billion; and royalties from the sales of ANORO® ELLIPTA®, which tier upward at a range from 6.5% to 10%. We expanded our portfolio through the acquisition of Entasis Therapeutics Holdings Inc. (“Entasis”) on July 11, 2022 and the acquisition of La Jolla Pharmaceutical Company (“La Jolla”) on August 22, 2022. Our commercial and marketed products include GIAPREZA® (angiotensin II), approved to increase blood pressure in adults with septic or other distributive shock, and XERAVA® (eravacycline) approved for the treatment of complicated intra-abdominal infections in adults. Our third product, XACDURO® (formerly known as sulbactam-durlobactam or SUL-DUR), was approved by the United States Food and Drug Administration (“FDA”) for the treatment of hospital-acquired and ventilator-associated pneumonias caused by Acinetobacter in adults on May 23, 2023. We commenced commercial sales of XACDURO® in the third quarter of 2023. Our development pipeline includes zoliflodacin, an investigational treatment for uncomplicated gonorrhea that reported positive data in a pivotal Phase 3 clinical trial on November 1, 2023. As such, we have a wholly owned robust critical care and infectious disease operating platform with a hospital focus anchored by three differentiated products with growth potential and a late-stage drug candidate. In addition, we own other strategic healthcare assets, such as a large equity stake in Armata Pharmaceuticals, a leader in development of bacteriophages with potential use across a range of infectious and other serious diseases. We also have economic interests in other healthcare companies.
Basis of Presentation	Basis of Presentation The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by U.S. GAAP for complete financial statements. The unaudited condensed consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and, in our opinion, include all adjustments, consisting of all normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending December 31, 2024, or any other periods. The accompanying unaudited condensed consolidated financial statements include the accounts of Innoviva, our wholly-owned subsidiaries, and certain variable interest entities (“VIEs”) for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2023 filed with the Securities and Exchange Commission (“SEC”) on February 29, 2024, and as amended on March 5, 2024 and March 22, 2024.
Use of Management's Estimates	Use of Management’s Estimates The preparation of unaudited condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. Management evaluates its significant accounting policies and estimates on an ongoing basis. We base our estimates on historical experience and other relevant assumptions that we believe to be reasonable under the circumstances. These estimates also form the basis for making judgments about the carrying values of assets and liabilities when these values are not readily apparent from other sources.
Concentrations of Credit Risk and of Significant Suppliers and Partner	Concentrations of Credit Risk and of Significant Suppliers and Partner Our financial instruments that are exposed to concentrations of credit risk consist primarily of cash and cash equivalents and equity and long-term investments. Although we deposit our cash with multiple financial institutions, our deposits, at times, may exceed federally insured limits. We are dependent on third-party manufacturers to supply active pharmaceutical ingredients (“API”) and drug products for research and development and commercial programs. These programs could be adversely affected by significant interruption in the supply of API or drug products. Currently, we derive most of our revenues from GSK. Our near-term success depends in large part upon the performance by GSK of its commercial obligations under the GSK Agreements and the commercial success of RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®. If GSK does not devote sufficient resources to the commercialization of these products, is unsuccessful in its efforts, or chooses to reprioritize its commercial programs, our business would be materially harmed. GSK is responsible for all clinical and other product development, regulatory, manufacturing and commercialization activities for products developed under the GSK Agreements, including RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®. Our quarterly royalty revenues may fluctuate due to a variety of factors, many of which are outside of our control. Our royalty revenues under the GSK Agreements may not meet our analysts’ or investors’ expectations due to a number of important factors. We also generate revenue from product sales of GIAPREZA® and XERAVA®. Additionally, we generate revenue from product sales of XACDURO®, which was commercially launched in September 2023. In the U.S., hospitals and other healthcare organizations generally acquire our products through a network of specialty distributors, which are regarded as our customers for accounting purposes. We do not believe that the loss of one of these distributors would significantly impact our ability to distribute our products, as we expect that sales volume would be absorbed by either new or remaining distributors. Three of our customers each account for 36%, 26% and 24%, respectively, of our net product sales for the three months ended March 31, 2024. These same customers account for 37%, 21% and 12%, respectively, of our receivables from net product sales, which are included in “Accounts receivables” in our unaudited condensed consolidated balance sheet as of March 31, 2024. Refer to Item 1A. “Risk Factors” disclosed in our Annual Report on Form 10-K for the year ended December 31, 2023.
Segment Reporting	Segment Reporting We operate in a single segment, focusing on providing capital return to stockholders by maximizing the potential value of our portfolio of royalties and innovative healthcare assets. Our Chief Executive Officer serves as our Chief Operating Decision Maker (“CODM”). The CODM allocates resources and evaluates Innoviva’s performance at the consolidated level using information about our revenues, operating results and other key financial data as needed.
Variable Interest Entities	Variable Interest Entities The primary beneficiary of a variable interest entity (“VIE”) is required to consolidate the assets and liabilities of the VIE. When we obtain a variable interest in another entity, we assess at the inception of the relationship and upon occurrence of certain significant events whether the entity is a VIE and, if so, whether we are the primary beneficiary of the VIE based on our power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and our obligation to absorb losses or the right to receive benefits from the VIE that could potentially be significant to the VIE. To assess whether we have the power to direct the activities of a VIE that most significantly impact the VIE’s economic performance, we consider all the facts and circumstances, including our role in establishing the VIE and our ongoing rights and responsibilities. This assessment includes identifying the activities that most significantly impact the VIE’s economic performance and identifying which party, if any, has power over those activities. In general, the parties that make the most significant decisions affecting the VIE (management and representation on the Board of Directors) and have the right to unilaterally remove those decision-makers are deemed to have the power to direct the activities of a VIE. To assess whether we have the obligation to absorb losses of the VIE or the right to receive benefits from the VIE that could potentially be significant to the VIE, we consider all of our economic interests that are deemed to be variable interests in the VIE. This assessment requires us to apply judgment in determining whether these interests, in the aggregate, are considered potentially significant to the VIE.
Cash and Cash Equivalents	Cash and Cash Equivalents We consider all highly liquid investments purchased with a maturity of three months or less on the date of purchase to be cash equivalents. Cash equivalents are carried at cost, which approximates fair value.
Accounts Receivable	Accounts Receivable Accounts receivables are recorded net of estimates for prompt-pay discounts, chargebacks, returns and rebates. Allowances for prompt-pay discounts and chargebacks are based on contractual terms. We estimate the allowance for credit losses based on existing contractual payment terms, actual payment patterns of customers and individual customer circumstances.
Inventory	Inventory Inventory is stated at the lower of cost or estimated net realizable value on a first in, first out basis. We periodically analyze inventory levels and write down inventory as cost of products sold when the following occurs: inventory has become obsolete, inventory has a cost basis in excess of its estimated net realizable value, or inventory quantities are in excess of expected product sales.
Goodwill and Intangible Assets	Goodwill and Intangible Assets Goodwill is recognized as the excess of the purchase consideration of an acquired entity over the fair value assigned to assets acquired and liabilities assumed in a business combination. Goodwill and intangible assets with an indefinite useful life are not amortized and are tested for impairment at least annually on the first day of December of each year or more frequently if indicators for potential impairment exist or whenever events or changes in circumstances indicate that the asset’s carrying asset amount may not be recoverable. Intangible assets with definite useful lives are amortized on a straight-line basis over their respective remaining useful lives and are tested for impairment only if indicators for potential impairment exist or whenever events or changes in circumstances indicate that the asset’s carrying amount may not be recoverable. Significant judgment may be involved in determining if an indicator of impairment has occurred.
Operating Leases	Operating Leases Right-of-use assets represent our right to use an underlying asset over the lease term and include any lease payments made prior to the lease commencement date and are reduced by lease incentives. Lease liabilities represent the present value of the total lease payments over the lease term, calculated using an estimated incremental borrowing rate. Lease expense is recognized on a straight-line basis over the expected lease term.
Equity and Long-Term Investments	Equity and Long-Term Investments We invest from time to time in equity and debt securities of private or public companies. If we determine that we have control over these companies under either voting or VIE models, we consolidate them in our unaudited condensed consolidated financial statements. If we determine that we do not have control over these companies under either voting or VIE models, we then determine if we have an ability to exercise significant influence via voting interests, board representation or other business relationships. We may account for the investments where we exercise significant influence using either an equity method of accounting or at fair value by electing the fair value option under Accounting Standards Codification (“ASC”) Topic 825, Financial Instruments. If the fair value option is applied to an investment that would otherwise be accounted for under the equity method, we apply it to all our financial interests in the same entity (equity and debt, including guarantees) that are eligible items. All gains and losses from fair value changes, unrealized and realized, are presented as changes in fair values of equity method investments, net, and changes in fair values of equity and long-term investments, net, within the unaudited condensed consolidated statements of income and comprehensive income. If we conclude that we do not have an ability to exercise significant influence over an investee, we may elect to account for the security without a readily determinable fair value using the measurement alternative method under ASC 321, Investments - Equity Securities. This measurement alternative method allows us to measure the equity investment at its cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer. We also invest in ISP Fund LP, which investments consist of money market funds, trading and equity securities in the healthcare, pharmaceutical and biotechnology industries. Pursuant to the Partnership Agreement entered in December 2020, we became a limited partner of this partnership, and our contributions are subject to a 36-month lock-up period which restriction prevents us from having control and access to the contributions and related investments. The lock-up period for a certain portion of our contributions expired in December 2023. We did not elect to make a withdrawal in 2023, thereby extending the lock-up period and withdrawal elections into subsequent years. These investments are classified as long-term investments in the unaudited condensed consolidated balance sheets.
Revenue Recognition	Revenue Recognition We apply the guidance on principal versus agent considerations under ASC Topic 606, Revenue from Contracts with Customers, to determine the appropriate treatment for the transactions between us and third parties. The classification of transactions under our arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. Any consideration related to activities in which we are considered the principal, which includes being in control of the good or service before such good or service is transferred to the customer, are accounted for as product sales. Revenue is recognized when our customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. Revenue is recognized through a five-step process: (i) identify the contract with the customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price for the contract; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue as a performance obligation is satisfied. Royalty Revenue We recognize the royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. The net sales reports provided by our partner are based on its methodology and assumptions to estimate rebates and returns, which it monitors and adjusts regularly in light of contractual and legal obligations, historical trends, past experience and projected market conditions. Our partner may make significant adjustments to its sales based on actual results recorded, which could cause our royalty revenue to fluctuate. We conduct periodic royalty audits to evaluate the information provided by our partner. Royalties are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK. Revenue from Product Sales Revenue from product sales is recognized when our customers obtain control of the product and is recorded at the transaction price, net of estimates for variable consideration consisting of chargebacks, discounts, returns and rebates. Variable consideration is estimated using the expected-value amount method, which is the sum of probability-weighted amounts in a range of possible consideration amounts. Actual amounts of consideration ultimately received may differ from our estimates. If actual results vary materially from our estimates, we will adjust these estimates, which will affect revenue from product sales and earnings in the period such estimates are adjusted. These items may include: • Chargebacks: Chargebacks are discounts we provide to distributors in the event that the sales prices to end users are below the distributors’ acquisition price. This may occur due to a direct contract with a health system, a group purchasing organization (“GPO”) agreement or a sale to a government facility. Chargebacks are estimated based on known chargeback rates and recorded as a reduction of revenue on delivery to our customers. • Discounts: We offer customers various forms of incentives and consideration, including prompt-pay and other discounts. We estimate discounts primarily based on contractual terms. These discounts are recorded as a reduction of revenue on delivery to our customers. • Returns: We offer customers a limited right of return, generally for damaged or expired product. We estimate returns based on an internal analysis, which includes actual experience. The estimates for returns are recorded as a reduction of revenue on delivery to our customers. • Rebates: We participate in Medicaid rebate programs, which provide assistance to certain low-income patients based on each individual state’s guidelines regarding eligibility and services. Under the Medicaid rebate programs, we pay a rebate to each participating state, generally within three months after the quarter in which product was sold. Additionally, we may offer customer incentives and consideration in the form of volume-based or other rebates. The estimates for rebates are recorded as a reduction of revenue on delivery to our customers. We continue to assess our estimates of variable consideration as we accumulate additional historical data and will adjust these estimates accordingly. License Revenue At the inception of a licensing arrangement that includes development and regulatory milestone payments, we evaluate whether the milestones are considered probable of being achieved and estimate the amount to be included in the transaction price. We generally include these milestone payments in the transaction price when they are achieved because there is considerable uncertainty in the research and development processes that trigger receipt of these payments under our agreements. Similarly, we include approval milestone payments in the transaction price once the product is approved by the applicable regulatory agency.
Research and Development Expenses	Research and Development Expenses Research and development expenses are recognized in the period that services are rendered or goods are received. Research and development expenses consist of salaries and benefits, laboratory supplies, facilities and other overhead costs, research-related manufacturing costs, contract service and clinical-related service costs performed by third party research organizations, research institutions and other outside service providers. Non-refundable prepayments for goods or services that will be used or rendered for future research and development activities are deferred and capitalized. Such amounts are recognized as an expense as the related goods are delivered or the related services are performed. We also utilize significant judgment and estimates to record accruals for estimated ongoing research costs based on the progress of the studies and progress of research manufacturing activities.
Interest Expense on Deferred Royalty Obligation	Interest Expense on Deferred Royalty Obligation Interest expense related to the deferred royalty obligation is recognized over the expected repayment term of the deferred royalty obligation using the effective interest method. The assumptions used in determining the expected repayment term of the deferred royalty obligation require us to make estimates that could impact the effective interest rate. Each reporting period, we estimate the expected repayment term of the deferred royalty obligation based on forecasted net sales of GIAPREZA®. Changes in interest expense resulting from changes in the effective interest rate, if any, are recorded on a prospective basis. Refer to Note 11, “Debt” for more information.
Related Party	Related Party Sarissa Capital owned 11.6% of our outstanding common stock as of March 31, 2024. Transactions with Sarissa Capital are described in Note 5, “Consolidated Entity”. Sarissa Capital is considered to be a related party because two of its principals are members of our board of directors. Recently Issued Accounting Pronouncements Not Yet Adopted In October 2023, the Financial Accounting Standards Board (“FASB”) issued ASU 2023-06, Disclosure Improvements: Codification Amendments in Response to the SEC’s Disclosure Update and Simplification Initiative. The amendment modifies the disclosure or presentation requirements for a variety of topics. The effective date for each amendment will be the date on which the SEC’s removal of that related disclosure from Regulation S-X or Regulation S-K becomes effective. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements. In November 2023, the FASB issued ASU 2023-07, Improvements to Reportable Segment Disclosures (Topic 280). This ASU update requires enhanced segment disclosures, primarily related to significant segment expenses. The amendments are effective for fiscal years beginning after December 15, 2023, and interim periods beginning after December 15, 2024. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements. In December 2023, the FASB issued ASU 2023-09, Improvements to Income Tax Disclosures (Topic 740). The ASU requires the disclosure of income taxes paid disaggregated by jurisdiction and enhanced disclosures for the entity’s effective tax rate reconciliation as well as other income tax related disclosures. The ASU is effective on a prospective basis for annual periods beginning after December 15, 2024. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements.
Recently Issued Accounting Pronouncements Not Yet Adopted	Recently Issued Accounting Pronouncements Not Yet Adopted In October 2023, the Financial Accounting Standards Board (“FASB”) issued ASU 2023-06, Disclosure Improvements: Codification Amendments in Response to the SEC’s Disclosure Update and Simplification Initiative. The amendment modifies the disclosure or presentation requirements for a variety of topics. The effective date for each amendment will be the date on which the SEC’s removal of that related disclosure from Regulation S-X or Regulation S-K becomes effective. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements. In November 2023, the FASB issued ASU 2023-07, Improvements to Reportable Segment Disclosures (Topic 280). This ASU update requires enhanced segment disclosures, primarily related to significant segment expenses. The amendments are effective for fiscal years beginning after December 15, 2023, and interim periods beginning after December 15, 2024. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements. In December 2023, the FASB issued ASU 2023-09, Improvements to Income Tax Disclosures (Topic 740). The ASU requires the disclosure of income taxes paid disaggregated by jurisdiction and enhanced disclosures for the entity’s effective tax rate reconciliation as well as other income tax related disclosures. The ASU is effective on a prospective basis for annual periods beginning after December 15, 2024. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements.

Commitments and Contingencies (Tables)

3 Months Ended

Mar. 31, 2024

Commitments and Contingencies Disclosure [Abstract]

Schedule of Components of Lease Cost

The components of lease cost are as follows:


	Three months ended March 31,
(In thousands)	2024		2023
Straight line operating lease costs	$	317	$	357
Variable lease costs		4		48
Total lease costs	$	321	$	405

Schedule of Supplemental Cash Flow Information Related to Leases

Supplemental cash flow information related to leases are as follows:


	Three months ended March 31,
(In thousands)	2024		2023
Cash paid for amounts included in the measurement of operating lease liabilities:	$	320	$	389

Schedule of Future Minimum Lease Payments

Future minimum payments on our operating leases as of March 31, 2024 were as follows:


(In thousands)	March 31, 2024
Years ending December 31:
Remainder of 2024	$	1,052
2025		1,428
2026		143
2027		149
Total undiscounted lease payments		2,772
Less: imputed interest		(200	)
Total operating lease liabilities	$	2,572

Income Taxes

3 Months Ended

Mar. 31, 2024

Income Tax Disclosure [Abstract]

Income Taxes

13. Income Taxes

We recorded a provision for income tax expense of $8.6 million and $6.3 million for the three months ended March 31, 2024 and 2023, respectively. The Company’s effective income tax rate for the three months ended March 31, 2024 was 19.0% compared to 15.3% for the same period in 2023. The income tax expense for the three months ended March 31, 2024 and 2023 was determined based upon estimates of the Company’s effective income tax rates in various jurisdictions. Our effective tax rate for the three months ended March 31, 2024 was lower than the expense computed at the U.S. federal statutory income tax rate due primarily to foreign-derived intangible income tax deduction and R&D credit, partially offset by non-deductible expenses and state income taxes.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480990/946-20-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h)(2))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//740/tableOfContent

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-14

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 21
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-21

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 270
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482526/740-270-50-1

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 17
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-17

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 6.I.5.Q1)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479360/740-10-S99-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 11.C)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479360/740-10-S99-2

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482603/740-30-50-2

+ Details

Net Income Per Share

3 Months Ended

Mar. 31, 2024

Earnings Per Share [Abstract]

Net Income Per Share

2. Net Income Per Share

Basic net income per share is computed by dividing net income by the weighted-average number of shares of common stock outstanding. Diluted net income per share is computed by dividing net income by the weighted-average number of shares of common stock and dilutive potential common stock equivalents then outstanding. Dilutive potential common stock equivalents include the assumed exercise, vesting and issuance of employee stock awards using the treasury stock method, as well as common stock issuable upon assumed conversion of our convertible subordinated notes due 2023 (the “2023 Notes”) up until its maturity date on January 15, 2023, our convertible senior notes due 2025 (the “2025 Notes”) and our convertible senior notes due 2028 (the “2028 Notes”) using the if-converted method.

The following table shows the computation of basic and diluted net income per share for the three months ended March 31, 2024 and 2023:


	Three Months Ended March 31,
(In thousands except per share data)	2024		2023
Numerator:
Net income, basic	$	36,532	$	34,865
Add: interest expense on 2023 Notes, net of tax effect		—		81
Add: interest expense on 2025 Notes, net of tax effect		1,121		1,169
Add: interest expense on 2028 Notes, net of tax effect		1,401		1,459
Net income, diluted	$	39,054	$	37,574
Denominator:
Weighted-average shares used to compute basic net income per share		63,185		67,786
Dilutive effect of 2023 Notes		—		757
Dilutive effect of 2025 Notes		11,150		11,150
Dilutive effect of 2028 Notes		9,956		9,956
Dilutive effect of options and awards granted under equity incentive plan and employee stock purchase plan		240		139
Weighted-average shares used to compute diluted net income per share		84,531		89,788
Net income per share
Basic	$	0.58	$	0.51
Diluted	$	0.46	$	0.42

Anti-Dilutive Securities

The following common stock equivalents were not included in the computation of diluted net income per share because their effect was anti-dilutive for the periods presented:


	Three Months Ended March 31,
(In thousands)	2024		2023
Outstanding options and awards granted under equity incentive plan and employee stock purchase plan		1,360		1,326
Outstanding stock warrant		591		591
Total		1,951		1,917

Stock-Based Compensation

3 Months Ended

Mar. 31, 2024

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

9. Stock-Based Compensation

Stock- Based Compensation Expense

The following table summarizes stock-based compensation expense:


	Three Months Ended March 31,
(In thousands)	2024		2023
Selling, general and administrative	$	1,358	$	1,152
Research and development		97		446
Total	$	1,455	$	1,598

Valuation Assumptions

Black-Scholes-Merton assumptions used in calculating the estimated value of stock options granted by Innoviva on the date of grant were as follows:


	Three Months Ended March 31,
	2024	2023
Risk-free interest rate	4.1% - 4.3%	3.7% - 4.0%
Expected term (in years)	5.90 - 6.15	5.16 - 6.11
Volatility	36.7% - 36.8%	38.1% - 38.5%
Dividend yield	0.0%	0.0%

Weighted-average estimated fair value of stock options granted	$4.97 - $6.93	$5.40 - $5.42

Net Income Per Share (Tables)

3 Months Ended

Mar. 31, 2024

Earnings Per Share [Abstract]

Schedule of computation of basic and diluted net income per share

The following table shows the computation of basic and diluted net income per share for the three months ended March 31, 2024 and 2023:


	Three Months Ended March 31,
(In thousands except per share data)	2024		2023
Numerator:
Net income, basic	$	36,532	$	34,865
Add: interest expense on 2023 Notes, net of tax effect		—		81
Add: interest expense on 2025 Notes, net of tax effect		1,121		1,169
Add: interest expense on 2028 Notes, net of tax effect		1,401		1,459
Net income, diluted	$	39,054	$	37,574
Denominator:
Weighted-average shares used to compute basic net income per share		63,185		67,786
Dilutive effect of 2023 Notes		—		757
Dilutive effect of 2025 Notes		11,150		11,150
Dilutive effect of 2028 Notes		9,956		9,956
Dilutive effect of options and awards granted under equity incentive plan and employee stock purchase plan		240		139
Weighted-average shares used to compute diluted net income per share		84,531		89,788
Net income per share
Basic	$	0.58	$	0.51
Diluted	$	0.46	$	0.42

Schedule of anti-dilutive securities

The following common stock equivalents were not included in the computation of diluted net income per share because their effect was anti-dilutive for the periods presented:


	Three Months Ended March 31,
(In thousands)	2024		2023
Outstanding options and awards granted under equity incentive plan and employee stock purchase plan		1,360		1,326
Outstanding stock warrant		591		591
Total		1,951		1,917

Balance Sheet Component - Schedule of Other Long-term Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Balance Sheet Related Disclosures [Abstract]
Long-term portion of deferred royalty obligation	$ 70,057	$ 69,876
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]	Total other long-term liabilities	Total other long-term liabilities
Long-term portion of lease liabilities	$ 1,304	$ 1,635
Contingent value rights liability	325	359
Total other long-term liabilities	$ 71,686	$ 71,870

Commitments and Contingencies - Schedule of Future Minimum Lease Payments (Details) $ in Thousands	Mar. 31, 2024 USD ($)
Commitments and Contingencies Disclosure [Abstract]
Remainder of 2024	$ 1,052
2025	1,428
2026	143
2027	149
Total undiscounted lease payments	2,772
Less: imputed interest	$ (200)
Operating Lease, Liability, Statement of Financial Position [Extensible Enumeration]	Liabilities and Equity
Total operating lease liabilities	$ 2,572

Consolidated Entities

3 Months Ended

Mar. 31, 2024

Consolidated Entities

Consolidated Entity

5. Consolidated Entity

ISP Fund LP

In December 2020, Innoviva Strategic Partners LLC, our wholly owned subsidiary (“Strategic Partners”), contributed $300.0 million to ISP Fund LP (the “Partnership”) for investing in “long” positions in the healthcare, pharmaceutical and biotechnology sectors and became a limited partner. The general partner of the Partnership (“General Partner”) is an affiliate of Sarissa Capital.

The Partnership Agreement provides for Sarissa Capital to receive management fees from the Partnership, payable quarterly in advance, measured based on the Net Asset Value of Strategic Partners’ capital account in the Partnership. In addition, General Partner is entitled to an annual performance fee based on the Net Profits of the Partnership during the annual measurement period.

The Partnership Agreement includes a lock-up period of thirty-six months after which Strategic Partners is entitled to make withdrawals from the Partnership as of such lock-up expiration date and each anniversary thereafter, subject to certain limitations. The lock-up period for the initial contribution of $190.0 million, which excludes the $110.0 million amount discussed below, expired in December 2023. Strategic Partners did not elect to make a withdrawal in 2023, thereby extending the lock-up period and withdrawal elections into subsequent years.

In May 2021, Strategic Partners received a distribution of $110.0 million from the Partnership to provide funding to Innoviva for a strategic repurchase of shares held by GSK. On March 30, 2022, Strategic Partners made an additional capital contribution of $110.0 million to the Partnership pursuant to the letter agreement entered into between Strategic Partners, the Partnership and Sarissa Capital Fund GP LP on May 20, 2021. The capital contribution is subject to a 36-month lock up period from the contribution date.

We consolidate ISP Fund LP under the VIE model as we have determined that ISP Fund LP is a VIE and we are the primary beneficiary of the entity via our related party relationships with Sarissa Capital entities. Our maximum exposure to loss is equal to the amount we invested in the entity.

ISP Fund LP is determined to be an investment company under ASC 946, Financial Services – Investment Companies, as it meets all fundamental characteristics of an investment company, and its activities are consistent with those of an investment company. Since ISP Fund LP is subject to investment company industry specific guidance, we have retained the industry-specific guidance applied by the Partnership. In addition, as our investment in the Partnership is a passive investment for the Company and is not part of our main operations, the investments are presented as part of “Equity and long-term investments” in our condensed consolidated balance sheets. We report in our condensed consolidated statements of income and comprehensive income any investment gains and losses by the Partnership as part of “Changes in fair value of equity and long-term investments, net”, any interest and dividend income as part of “Interest and dividend income” and any investment expenses as part of “Other expense, net”.

As of March 31, 2024, we continued to hold approximately 100% of the economic interest of the Partnership. As of March 31, 2024 and December 31, 2023, total assets of the Partnership were $287.2 million and $311.8 million, respectively, of which the majority was attributable to equity and long-term investments. As of March 31, 2024 and December 31, 2023, total liabilities were $1.8 million and $0.1 million, respectively. The partnership’s assets can only be used to settle its own obligations. During the three months ended March 31, 2024, we recorded $0.2 million of net investment-related expense incurred by the Partnership and $26.2 million of net negative changes in fair values of equity and long-term investments in the unaudited condensed consolidated statements of income and comprehensive income. During the three months ended March 31, 2023, we recorded $0.5 million of net investment-related expenses incurred by the Partnership and $4.1 million of net negative changes in fair values of equity and long-term investments in the unaudited condensed consolidated statements of income and comprehensive income.

Equity and Other Investments and Fair Value Measurements - Equity Investment in ImaginAb (Details) $ in Thousands				3 Months Ended
	Sep. 14, 2023 USD ($) shares	Mar. 14, 2023 USD ($) shares	Mar. 18, 2021 USD ($) shares	Mar. 31, 2024 USD ($) Director	Feb. 23, 2024 USD ($)	Dec. 31, 2023 USD ($)
Equity Investment
Total purchase price				$ 453,500		$ 453,500
ImaginAb
Equity Investment
Transaction costs to acquire equity securities			$ 400
Number of Investee's Board members currently representing the Company \| Director				1
ImaginAb \| Consolidated Investees [Member]
Equity Investment
Equity investment ownership percentage				11.80%		12.40%
ImaginAb \| Series C preferred stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares			4,051,724
Amount of securities purchase agreement			$ 4,700
ImaginAb \| Series C-2 preferred stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares	405,852	270,568
Amount of securities purchase agreement	$ 600	$ 600
ImaginAb \| Series C preferred stock, Series C-2 preferred stock and common stock
Equity Investment
Equity and long-term investments at fair value				$ 7,600		$ 7,600
ImaginAb \| ImaginAb Convertible Note
Equity Investment
Total purchase price					$ 2,700
Debt Instrument, annual interest rate					10.00%
Unrealized loss from fair value changes in equity investments				200
Equity and long-term investments at fair value				$ 2,900
ImaginAb \| One of ImaginAb's Common Stockholders \| Common stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares			4,097,157
Amount of securities purchase agreement			$ 1,300

Stock-Based Compensation - Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Stock-based compensation
Total stock-based compensation expense	$ 1,455	$ 1,598
Selling, general and administrative
Stock-based compensation
Total stock-based compensation expense	1,358	1,152
Research and development
Stock-based compensation
Total stock-based compensation expense	$ 97	$ 446

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 1D
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480483/718-10-35-1D

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 35
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-URI https://asc.fasb.org//1943274/2147480483/718-10-35-3

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

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-Section 50
-Paragraph 2
-Subparagraph (a)(3)
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-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
-Section 50
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-Subparagraph (c)(1)(iv)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Income Tax Disclosure [Abstract]
Income tax expense, net	$ 8,592	$ 6,275
Effective tax rate (as a percent)	19.00%	15.30%

- Definition

Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References + Details

Consolidated Entities and Acquisitions - Entasis Therapeutics Holdings, Inc. (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Subsidiary or Equity Method Investee [Line Items]
Total purchase price	$ 453,500		$ 453,500
Net loss attributable to Innoviva stockholders	$ 36,532	$ 34,865

- Definition

Amount, after deduction of tax, noncontrolling interests, dividends on preferred stock and participating securities; of income (loss) available to common shareholders.

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+ Details

Equity and Other Investments and Fair Value Measurements - Equity Investment in Nanolive (Details) - Nanolive SFr in Millions, $ in Millions	Feb. 18, 2022 CHF (SFr) shares	Feb. 18, 2022 USD ($) shares	Mar. 31, 2024 USD ($) Director	Dec. 31, 2023 USD ($)
Equity Investment
Transaction costs to acquire equity securities \| $		$ 0.7
Number of Investee's Board members currently representing the Company \| Director			0
Number of the Investee's Board members \| Director			7
Fair value of equity securities \| $			$ 10.6	$ 10.6
Consolidated Investees [Member]
Equity Investment
Equity investment ownership percentage			15.30%	15.30%
Series C preferred stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares	18,750,000	18,750,000
Amount of securities purchase agreement	SFr 9.0	$ 9.8

Debt (Tables)

3 Months Ended

Mar. 31, 2024

Debt

Schedule of Debt

Our debt consists of the following:


	March 31,			December 31,
(In thousands)	2024			2023
2025 Notes	$	192,500		$	192,500
2028 Notes		261,000			261,000
Total debt		453,500			453,500
Less: Unamortized debt discount and issuance costs		(6,741	)		(7,266	)
Total long-term debt, net	$	446,759		$	446,234

Aggregate Scheduled Maturities of Convertible Debt

The aggregate scheduled maturities of our convertible debt as of March 31, 2024 were as follows:


(In thousands)	March 31, 2024
Years ending December 31:
Remainder of 2024	$	—
2025		192,500
2026		—
2027		—
2028		261,000
Total	$	453,500

2025 Notes

Debt

Summary of Liability and Equity Components of Convertible Notes

Our outstanding 2025 Notes balances consisted of the following:


	March 31,			December 31,
(In thousands)	2024			2023
Principal	$	192,500		$	192,500
Debt discount and issuance costs, net		(1,024	)		(1,205	)
Net carrying amount	$	191,476		$	191,295

Schedule of Components of Interest Expense

The following table sets forth total interest expense recognized related to the 2025 Notes for the three months ended March 31, 2024 and 2023:


	Three Months Ended March 31,
(In thousands)	2024		2023
Contractual interest expense	$	1,203	$	1,203
Amortization of debt issuance costs		181		176
Total interest and amortization expense	$	1,384	$	1,379

2028 Notes

Debt

Summary of Liability and Equity Components of Convertible Notes

Our outstanding 2028 Notes balance consisted of the following:


	March 31,			December 31,
(In thousands)	2024			2023
Principal	$	261,000		$	261,000
Debt issuance costs, net		(5,717	)		(6,061	)
Net carrying amount	$	255,283		$	254,939

Schedule of Components of Interest Expense

The following table sets forth total interest expense recognized related to the 2028 Notes for the three months ended March 31, 2024 and 2023:


	Three months ended March 31,
(In thousands)	2024		2023
Contractual interest expense	$	1,387	$	1,387
Amortization of debt issuance costs		344		335
Total interest and amortization expense	$	1,731	$	1,722

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

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+ Details

Revenue Recognition (Tables)

3 Months Ended

Mar. 31, 2024

Revenue from Contract with Customer [Abstract]

Schedule of net revenue from collaboration arrangement

Net revenue recognized under our GSK Agreements was as follows:


	Three Months Ended March 31,
(In thousands)	2024			2023
Royalties - RELVAR/BREO	$	52,138		$	50,883
Royalties - ANORO		9,733			9,431
Total royalties		61,871			60,314
Less: amortization of capitalized fees paid		(3,456	)		(3,456	)
Total net royalty revenue	$	58,415		$	56,858

Subsequent Event

3 Months Ended

Mar. 31, 2024

Subsequent Events [Abstract]

Subsequent Event

14. Subsequent Event

On April 11, 2024, we entered into a Commercial Supply Agreement with Corden Pharma CHENÔVE SAS (“Corden”), under which we engaged Corden to manufacture and supply certain products related to XACDURO® and to perform certain services and studies. Under the agreement, we committed to minimum purchase commitments aggregating to approximately $30.0 million through December 31, 2027.

Commitments and Contingencies (Additional Information) (Details)	Mar. 31, 2024
Lessee, Lease, Description [Line Items]
Operating lease, Weighted average remaining lease term	2 years 1 month 6 days
Weighted average discount rate	7.50%

Equity and Other Investments and Fair Value Measurements

3 Months Ended

Mar. 31, 2024

Fair Value Disclosures [Abstract]

Equity and Other Investments and Fair Value Measurements

6. Equity and Other Investments and Fair Value Measurements

Equity Investment in Armata

During the first quarter of 2020, Innoviva acquired 8,710,800 shares of common stock as well as warrants to purchase 8,710,800 additional shares of common stock of Armata Pharmaceuticals, Inc. (“Armata”) for approximately $25.0 million in cash. Armata is a clinical stage biotechnology company focused on precisely targeted bacteriophage therapeutics for antibiotic-resistant infections.

During the first quarter of 2021, ISO entered into a securities purchase agreement with Armata to acquire 6,153,847 shares of Armata common stock and warrants to purchase 6,153,847 additional shares of Armata common stock for approximately $20.0 million. Armata also entered into a voting agreement with the Company and ISO, pursuant to which the Company and ISO agreed not to vote or take any action by written consent with respect to any common shares held by the Company and ISO that represent, in the aggregate, more than 49.5% of the total number of shares of Armata’s common stock for voting on the matters related to election or removal of Armata’s board members. The voting agreement will expire the earlier of the second anniversary of the agreement effective date and approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. During the fourth quarter of 2021, ISO also purchased an additional 1,212,122 shares of Armata common stock for approximately $4.0 million.

On February 9, 2022, ISO entered into a securities purchase agreement with Armata to acquire 9,000,000 shares of Armata common stock and warrants to purchase 4,500,000 additional shares of common stock with an exercise price of $5.00 per share for $45.0 million. The investment closed in two tranches on February 9, 2022 and March 31, 2022. The investment is intended to aid Armata in advancing its clinical pipeline and strengthening its bacteriophage platform. On February 9, 2022, Armata also entered a second amended and restated voting agreement with the Company and ISO, pursuant to which the Company and ISO agreed not to vote or take any action by written consent with respect to any common shares held by the Company and ISO that represent, in the aggregate, more than 49.5% of the total number of shares of Armata’s common stock for voting on the matters related to election or removal of Armata’s board members or amend the bylaws of Armata to reduce the maximum number of directors or set the number of directors who may serve on the board of Armata. The voting agreement will expire the earlier of the second anniversary of the agreement effective date and approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. In addition, as of February 9, 2022, Armata entered into an amended and restated investor rights agreement with the Company and ISO, pursuant to which for as long as the Company and ISO hold at least 12.5% of the outstanding shares of Armata’s common stock on a fully-diluted, the Company and ISO shall have the right to designate two directors to Armata’s board of directors, and for so long as the Company and ISO hold at least 8%, but less than 12.5%, of the outstanding shares of Armata’s common stock on a fully-diluted basis, the Company and ISO shall have the right to designate one director to Armata’s board of directors, subject to certain conditions and qualifications set forth in the amended and restated investor rights agreement. On July 10, 2023, Armata entered into an amendment to the amended and restated investor rights agreement with the Company and ISO, pursuant to which the Company and ISO agreed that the voting agreement will expire on the earlier of the fifth anniversary of the original agreement's effective date, January 26, 2021, or the approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. As of March 31, 2024, three of the seven members of Armata’s board of directors are also members of the board of directors of Innoviva. As of March 31, 2024 and December 31, 2023, the Company and ISO owned approximately 69.4%, of Armata’s common stock.

On January 10, 2023, we entered into a Secured Convertible Credit Agreement (the “Credit Agreement”) with Armata, under which we extended a one-year convertible note (the “Armata Convertible Note”) in an aggregate amount of $30.0 million at an interest rate of 8.0% per annum. Pursuant to the Credit Agreement, the balance on the Armata Convertible Note, including all accrued and unpaid interest thereon, will convert into shares of Armata's common stock upon the occurrence of a qualified financing, as defined in the Credit Agreement. Any portion of the balance on the Armata Convertible Note, including all accrued and unpaid interest thereon, may also be converted into shares of Armata's common stock at our option once a registration statement covering the resale of such securities has been declared effective by the SEC. The Armata Convertible Note is secured by substantially all of the assets of Armata and its domestic and foreign material subsidiaries. On July 10, 2023, ISO and Armata executed an amendment to the Armata Convertible Note extending the maturity date from January 10, 2024 to January 10, 2025.

On July 10, 2023, ISO and Armata entered into a Credit and Security Agreement (the “July 2023 Credit and Security Agreement”), under which we extended a term loan to Armata (the “Armata July 2023 Term Loan”) in an aggregate amount of $25.0 million. The Armata July 2023 Term Loan is subject to an interest rate of 14% per annum and is due to mature on January 10, 2025. The July 2023 Credit and Security Agreement is secured by substantially all of the assets of Armata and its domestic and foreign material subsidiaries.

On March 4, 2024, ISO and Armata entered into a Credit and Security Agreement (the “March 2024 Credit and Security Agreement”), under which we extended a term loan to Armata (the “Armata March 2024 Term Loan”) in an aggregate amount of $35.0 million. The Armata March 2024 Term Loan is subject to an interest rate of 14% per annum and is due to mature on June 4, 2025. The March 2024 Credit and Security Agreement is secured by substantially all of the assets of Armata and its domestic and foreign material subsidiaries.

The investments in Armata’s common stock and warrants provide Innoviva and ISO the ability to have significant influence, but not control over Armata’s operations. Armata’s business and affairs are managed under the direction of its board of directors, which Innoviva and ISO do not control. Based on our evaluation, we determined that Armata is a VIE, but Innoviva and ISO are not the primary beneficiary of the VIE. We have not provided financial or other support that we were not previously contractually required to provide during the periods presented. Our maximum exposure to loss is equal to the amount we invested in the entity.

We account for Armata’s common stock and warrants under the equity method using the fair value option. The fair value of Armata’s common stock is measured based on its closing market price. The warrants purchased in 2020, 2021 and 2022 have an exercise price of $2.87, $3.25 and $5.00 per share, respectively. All warrants are exercisable immediately within five years from the issuance date of the warrants and include a cashless exercise option. We use the Black-Scholes-Merton pricing model to estimate the fair value of these warrants with the following input assumptions: Armata’s closing market price on the valuation date, the risk-free interest rate computed based on the U.S. Treasury yield, the remaining contractual term as the expected term, and the expected stock price volatility calculated based on the historical volatility of the common stock of Armata and its peer companies. We account for the Armata Convertible Note as a trading security, measured at fair value using a Monte Carlo simulation model with the probability of certain qualified events and the assumptions of risk-free rate, volatility of stock price and timing of certain qualified events. We account for the Armata July 2023 Term Loan and the Armata March 2024 Term Loan as trading securities, measured at fair value using income approach based on the discounted value of expected future cash flows.

As of March 31, 2024, the fair values of our holdings of Armata common stock, warrants, the Armata Convertible Note, the Armata July 2023 Term Loan and the Armata March 2024 Term Loan were estimated at $104.8 million, $47.1 million, $64.3 million, $27.4 million, and $35.5 million, respectively. As of December 31, 2023, the fair values of our holdings of Armata common stock, warrants, the Armata Convertible Note and the Armata July 2023 Term Loan were estimated at $81.2 million, $35.3 million, $51.9 million and $27.0 million, respectively.

For the Armata common stock and warrants, we recorded $35.3 million and $15.8 million in unrealized gain for the three months ended March 31, 2024 and 2023, respectively, as changes in fair values of equity method investments, net, in the unaudited condensed consolidated statements of income and comprehensive income. For the Armata Convertible Note, we recorded $12.4 million and $2.8 million unrealized gain as changes in fair values of equity and long-term investments, net, in the unaudited condensed consolidated statements of income and comprehensive income for three months ended March 31, 2024 and 2023, respectively. For the July 2023 Armata Term Loan, we recorded $0.4 million unrealized gain as changes in fair values of equity and long-term investments, net, in the unaudited condensed consolidated statements of income and comprehensive income for three months ended March 31, 2024. For the March 2024 Armata Term Loan, we recorded $0.5 million unrealized gain as changes in fair values of equity and long-term investments, net, in the unaudited condensed consolidated statements of income and comprehensive income for three months ended March 31, 2024.

The summarized financial information, including the portion we do not own, is presented for Armata on a one quarter lag as follows:

Income Statement Information


	Three Months Ended December 31,
(In thousands)	2023			2022
Revenue	$	1,528		$	1,051
Loss from operations	$	(6,578	)	$	(10,328	)
Net loss	$	(19,847	)	$	(10,314	)

Equity Investment in InCarda

During the third quarter of 2020, TRC purchased 20,469,432 shares of Series C preferred stock and a warrant to purchase 5,117,358 additional shares of Series C preferred stock of InCarda Therapeutics, Inc. (“InCarda”) (the “InCarda 2020 Warrant”) for $15.8 million, which included $0.8 million of transaction costs. InCarda is a privately held biopharmaceutical company focused on developing inhaled therapies for cardiovascular diseases. The investment is intended to fund the ongoing clinical development of InRhythmTM (flecainide for inhalation), InCarda’s lead program, for the treatment of a recent-onset episode of paroxysmal atrial fibrillation. On July 20, 2022, under the terms of the TRC Equity Purchase Agreement, TRC transferred to Innoviva’s wholly-owned subsidiary, Innoviva TRC Holdings, LLC (“ITH”) all of TRC’s ownership interests and investments in InCarda. ITH has the right to designate one member to InCarda’s board of directors. As of March 31, 2024, none of InCarda’s six board members was designated by ITH. We did not exercise the InCarda 2020 Warrant which expired in March 2023 and wrote off its carrying value of $0.1 million during the three months ended March 31, 2023.

On March 9, 2022, TRC entered into a Note and Warrant Purchase Agreement (the “InCarda Agreement”) with InCarda to acquire a convertible promissory note (the “InCarda 2022 Convertible Note”) and warrants (the “InCarda 2022 Warrant”) for $0.7 million. The InCarda 2022 Warrant expires on March 9, 2027 and is measured at fair value.

On June 15, 2022, the principal amount and the accrued interest of the InCarda 2022 Convertible Note were converted into equity securities. In addition, TRC participated in InCarda’s Series D preferred stock financing by investing $2.3 million. In connection with the new round of financing, InCarda recapitalized its equity structure resulting in TRC owning 4,093,886 shares of InCarda’s common stock, 37,350 shares of its Series A-1 preferred stock, 20,469,432 shares of its Series C preferred stock, 8,771,780 shares of its Series D-1 preferred stock, 3,369,802 shares of its Series D-2 preferred stock, a warrant to purchase 5,117,358 shares of its Series C preferred stock at $0.73 per share and a warrant to purchase 2,490,033 shares of its Series D-1 preferred stock at $0.20 per share.

Due to certain changes in InCarda’s business operations during the second quarter of 2023, ITH reassessed the value of its investments in InCarda using the Option Pricing Model methodology. Key assumptions used in the valuation model included an expected holding period of two years, a risk-free interest rate of 4.9%, a dividend yield of 0.0% and an estimated volatility of 114.2%. The estimated volatility was calculated based on the historical volatility of a selected peer group of public companies comparable to InCarda. We recognized an impairment charge of $2.9 million during the second quarter of 2023.

On January 17, 2024, ITH purchased a secured convertible promissory note (the “InCarda Convertible Note”) from InCarda for a total purchase price of $0.4 million. The InCarda Convertible Note bears an annual interest rate of 8% and shall be due and payable upon the earlier to occur of certain events defined in the InCarda Convertible Note. The InCarda Convertible Note will convert into equity securities or shadow equity securities of InCarda depending upon the occurrence of a qualified event or a qualified financing event as also defined in the InCarda Convertible Note. The InCarda Convertible Note is secured by certain intellectual property rights of InCarda.

As of March 31, 2024 and December 31, 2023, we held 8.1% of InCarda equity ownership. Our investment in InCarda does not provide us with the ability to control or have significant influence over InCarda’s operations. Based on our evaluation, we determined that InCarda is a VIE, but we are not the primary beneficiary of the VIE. We have not provided financial or other support that we were not previously contractually required to provide during the periods presented. Our maximum exposure to loss is equal to the amount we invested in the entity.

With the exception of the InCarda Convertible Note and the InCarda Series D Warrants, we account for our investments in InCarda under the measurement alternative. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. Due to InCarda’s equity recapitalization in the second quarter of 2022, TRC reassessed the value of its investments in InCarda using the Option Pricing Model Backsolve valuation methodology. Key assumptions used in the valuation model included an expected holding period of two years, a risk-free interest rate of 3.2%, a dividend yield of 0.0% and an estimated volatility of 122.0%. The estimated volatility was calculated based on the historical volatility of a selected peer group of public companies comparable to InCarda. We recognized an impairment charge of $9.0 million during the second quarter of 2022. We account for the InCarda Convertible Note as a trading security, measured at fair value.

As of March 31, 2024 and December 31, 2023, we recorded as equity and long-term investments in the unaudited condensed consolidated balance sheets $4.8 million in fair value of InCarda’s Series C preferred stock and $0.1 million in fair value of the InCarda Series D Warrants. As of March 31, 2024 and December 31, 2023, we recognized as equity and long-term investments in the unaudited condensed consolidated balance sheets $2.7 million, for InCarda’s Series D-1 preferred stock, Series D-2 preferred stock, and common stock using the measurement alternative. As of March 31, 2024, we recorded $0.4 million in fair value of the InCarda Convertible Note as equity and long-term investments in the unaudited condensed consolidated balance sheet. During the three months ended March 31, 2024, there was immaterial change in the carrying amount of our investments. During the three months ended March 31, 2023, we recorded $0.1 million in net unrealized loss as changes in fair values of equity and long-term investments, net in the unaudited condensed consolidated statements of income and comprehensive income.

Equity Investment in ImaginAb

On March 18, 2021, TRC entered into a securities purchase agreement with ImaginAb, to purchase 4,051,724 shares of ImaginAb Series C preferred stock for $4.7 million. On the same day, TRC also entered into a securities purchase agreement with one of ImaginAb’s common stockholders to purchase 4,097,157 shares of ImaginAb common stock for $1.3 million. ImaginAb is a privately held biotechnology company focused on clinically managing cancer and autoimmune diseases via molecular imaging. $0.4 million was incurred for investment due diligence costs and execution and recorded as part of the equity investment in the condensed consolidated balance sheets.

On July 20, 2022, under the terms of the TRC Equity Purchase Agreement, TRC transferred to ITH all of TRC’s ownership interests and investments in ImaginAb.

On March 14, 2023, ITH entered into a securities purchase agreement with ImaginAb to purchase 270,568 shares of ImaginAb Series C-2 preferred stock for $0.6 million. On September 14, 2023, ITH entered into a securities purchase agreement with ImaginAb to purchase another 405,852 shares of ImaginAb Series C-2 preferred stock for $0.6 million.

On February 23, 2024, ITH purchased a subordinated convertible promissory note (the “ImaginAb Convertible Note”) from ImaginAb for a total purchase price of $2.7 million. The ImaginAb Convertible Note bears an annual interest rate of 10% and shall be due and payable upon the earlier to occur of January 31, 2025 and certain events defined in the ImaginAb Convertible Note. Under certain circumstances, the ImaginAb Convertible Note is convertible at the option of ITH into ImaginAb’s equity securities at defined conversion prices. The ImaginAb Convertible Note is subordinate to certain existing indebtedness of ImaginAb as defined in the ImaginAb Convertible Note.

As of March 31, 2024, one of ImaginAb’s six board members was designated by ITH. As of March 31, 2024 and December 31, 2023, we held 11.8% and 12.4%, respectively, of ImaginAb equity ownership.

Our investment in ImaginAb does not provide us with the ability to control or have significant influence over ImaginAb’s operations. Based on our evaluation, we determined that ImaginAb is a VIE, but we are not the primary beneficiary of the VIE. We have not provided financial or other support that we were not previously contractually required to provide during the periods presented. Our maximum exposure to loss is equal to the amount we invested in the entity.

Because ImaginAb’s equity securities are not publicly traded and do not have a readily determinable fair value, we account for our investment in ImaginAb’s Series C preferred stock, Series C-2 preferred stock and common stock using the measurement alternative. We account for the ImaginAb Convertible Note as a trading security, measured at fair value using a Monte Carlo simulation model with the probability of certain qualified events and the assumptions of risk-free rate, volatility of stock price and timing of certain qualified events. As of March 31, 2024 and December 31, 2023, our investment in ImaginAb’s Series C preferred stock, Series C-2 preferred stock and common stock amounted to $7.6 million and recorded as equity and long-term investments in the unaudited condensed consolidated balance sheets. As of March 31, 2024, we recorded $2.9 million in fair value of the ImaginAb Convertible Note as equity and long-term investments in the unaudited condensed consolidated balance sheet. During the three months ended March 31, 2024, we recorded $0.2 million in net unrealized loss on the ImaginAb Convertible Note as changes in fair values of equity and long-term investments, net in the unaudited condensed consolidated statements of income and comprehensive income. There was no change in the carrying amount of our equity investments in ImaginAb.

Convertible Promissory Note in Gate Neurosciences

On November 24, 2021, TRC entered into a Convertible Promissory Note Purchase Agreement with Gate to acquire a convertible promissory note (the “Gate Convertible Note”) with a principal amount of $15.0 million. Gate is a privately held biopharmaceutical company focused on developing the next generation of targeted nervous system therapies, leveraging precision medicine approaches to develop breakthrough drugs for psychiatric and neurologic diseases. The investment is intended to fund Gate's ongoing development and research. The Gate Convertible Note bears an annual interest rate of 8% and will convert into shares of common stock of Gate upon a qualified event or into shares of shadow preferred stock of Gate (“Shadow Preferred”) upon a qualified financing. A qualifying event can be a qualified initial price offering, a qualified merger, or a merger with a special-purpose acquisition company (“SPAC”). Shadow Preferred means preferred stock having identical rights, preferences and restrictions as the preferred stock that would be issued in a qualified financing.

The number of common stock shares to be issued in a qualified event shall be equal to the amount due on the conversion date divided by the lesser of a capped conversion price (the “Capped Conversion Price”) and the qualified event price (the “Qualified Event Price”). The Capped Conversion Price is calculated as $50.0 million divided by the number of shares of common stock outstanding at such time on a fully diluted basis. The Qualified Event Price is the price per share determined by the qualified event. A qualified financing is a sale or series of sales of preferred stock where (i) at least 50 percent of counterparties are not existing shareholders, (ii) net proceeds to Gate are at least $35.0 million, and (iii) the stated or implied equity valuation of Gate is at least $80.0 million.

On July 20, 2022, under the terms of the TRC Equity Purchase Agreement, TRC transferred to ITH all of TRC’s debt investments in Gate.

On February 2, 2023, ITH entered into a Note Amendment Agreement (the “Note Amendment Agreement”) with Gate to amend the Gate Convertible Note. Pursuant to the Note Amendment Agreement, the principal amount of the Gate Convertible Note was increased from $15.0 million to $21.5 million, which represents the original principal and accrued interest as of the first amendment date and an additional cash investment of $5.0 million. All other material terms of the Gate Convertible Note were unchanged.

On October 6, 2023, ITH entered into a Second Note Amendment Agreement with Gate to amend the Note Amendment Agreement. Pursuant to the Second Note Amendment Agreement, the principal amount of the Gate Convertible Note was increased from $21.5 million to $27.7 million, which represents the principal and accrued interest as of the second amendment date and an additional cash investment of $5.0 million. All other material terms of the Gate Convertible Note were unchanged.

On February 13, 2024, ITH entered into a Third Note Amendment Agreement with Gate to amend the Gate Convertible Note. Pursuant to the Third Note Amendment Agreement, the principal amount of the Gate Convertible Note was increased from $27.7 million to $33.5 million, which represents the principal and accrued interest as of the third amendment date and an additional cash investment of $5.0 million. All other material terms of the Gate Convertible Note were unchanged.

We have accounted for the Gate Convertible Note as a trading security, measured at fair value using a Monte Carlo simulation model with the probability of certain qualified events and the assumptions of equity value of Gate, risk-free rate, expected stock price, volatility of its peer companies, and the time until a financing is raised. As of March 31, 2024 and December 31, 2023, the fair value of the Gate Convertible Note was estimated at $33.2 million and $28.0 million, respectively, and recorded as equity and long-term investments in the unaudited condensed consolidated balance sheets. We recorded $0.6 million and $0.7 million unrealized loss as changes in fair values of equity and long-term investments, net in the unaudited condensed consolidated statements of income and comprehensive income for the three months ended March 31, 2024 and 2023, respectively.

Equity Investment in Nanolive

On February 18, 2022, TRC entered into an investment and shareholders agreement with Nanolive to purchase 18,750,000 shares of Nanolive Series C preferred stock for $9.8 million (equivalent to 9.0 million CHF). Nanolive SA is a Swiss privately held life sciences company focused on developing breakthrough imaging solutions that accelerate research in growth industries such as drug discovery and cell therapy. $0.7 million was incurred for investment due diligence costs and execution and recorded as part of the equity and long-term investment in the condensed consolidated balance sheets. On July 20, 2022, under the terms of the TRC Equity Purchase Agreement, TRC transferred to ITH all of TRC’s ownership interests and investments in Nanolive. ITH has the right to designate one member to Nanolive’s board. ITH also has the right to designate another member, who will be mutually acceptable to ITH and another stockholder, to Nanolive’s board. As of March 31, 2024, no Innoviva designee is serving on Nanolive’s seven-member board. As of March 31, 2024 and December 31, 2023, we held 15.3% of Nanolive equity ownership.

Our investment in Nanolive does not provide us with the ability to control or have significant influence over Nanolive’s operations. Based on our evaluation, we determined that Nanolive is a VIE, but we are not the primary beneficiary of the VIE. We have not provided financial or other support that we were not previously contractually required to provide during the periods presented. Our maximum exposure to loss is equal to the amount we invested in the entity.

Because Nanolive’s equity securities are not publicly traded and do not have a readily determinable fair value, we account for our investment in Nanolive’s Series C preferred stock using the measurement alternative. As of March 31, 2024 and December 31, 2023, $10.6 million was recorded as equity and long-term investments in the unaudited condensed consolidated balance sheets and there was no change to the carrying amount of our investment.

Available-for-Sale Securities

The estimated fair value of available-for-sale securities is based on quoted market prices for these investments that were based on prices obtained from a commercial pricing service. Available-for-sale securities are summarized below:


	March 31, 2024
			Gross		Gross
	Amortized		Unrealized		Unrealized		Estimated
(In thousands)	Cost		Gains		Losses		Fair Value
Money market funds(1)	$	151,836	$	—	$	—	$	151,836
Total	$	151,836	$	—	$	—	$	151,836

(1) Money market funds are included in cash and cash equivalents in the condensed consolidated balance sheets.


	December 31, 2023
			Gross		Gross
	Amortized		Unrealized		Unrealized		Estimated
(In thousands)	Cost		Gains		Losses		Fair Value
Money market funds (1)	$	170,706	$	—	$	—	$	170,706
Total	$	170,706	$	—	$	—	$	170,706

(1) Money market funds are included in cash and cash equivalents in the condensed consolidated balance sheets.

As of March 31, 2024 and December 31, 2023, all investments were money market funds, and there was no credit loss recognized.

Fair Value Measurements

Our available-for-sale securities, equity and long-term investments and contingent value rights are measured at fair value on a recurring basis and our debt is carried at amortized cost basis.


	Estimated Fair Value Measurements as of March 31, 2024 Using:
	Quoted Price in Active Markets for		Significant Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	151,836	$	—	$	—	$	151,836
Investments held by ISP Fund LP (1)		225,521		—		61,618		287,139
Equity investment - Armata Common Stock		104,821		—		—		104,821
Equity investment - Armata Warrants		—		47,067		—		47,067
Equity investment - InCarda Warrants		—		—		75		75
Convertible debt investment - Armata Note		—		—		64,254		64,254
Term loan investment - Armata July 2023 Term Loan		—		—		27,426		27,426
Term loan investment - Armata March 2024 Term Loan		—		—		35,479		35,479
Convertible debt investment - InCarda Note		—		—		436		436
Convertible debt investment - ImaginAb Note		—		—		2,894		2,894
Convertible debt investment - Gate Note		—		—		33,201		33,201
Total assets measured at estimated fair value	$	482,178	$	47,067	$	225,383	$	754,628
Liabilities
Debt
2025 Notes	$	—	$	205,325	$	—	$	205,325
2028 Notes		—		230,333		—		230,333
Total fair value of debt	$	—	$	435,658	$	—	$	435,658
Contingent value rights		—		—		325		325
Total liabilities measured at estimated fair value	$	—	$	435,658	$	325	$	435,983

(1)

The investments held by ISP Fund LP consisted of $225.7 million in equity investments, which included private placement positions of $61.6 million, and $61.4 million in money market funds, cash and interest receivable. A certain portion of the total capital contribution of $300.0 million is no longer subject to a 36-month lock-up period from the date of such capital contribution. However, we did not elect to make a withdrawal in 2023, thereby extending the lock-up period and withdrawal elections into subsequent years.


	Estimated Fair Value Measurements as of December 31, 2023 Using:
	Quoted Price
	in Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	170,706	$	—	$	—	$	170,706
Investments held by ISP Fund LP (1)		251,207		—		60,605		311,812
Equity investment - Armata Common Stock		81,249		—		—		81,249
Equity investment - Armata Warrants		—		35,297		—		35,297
Convertible debt investment - Armata Note						51,883		51,883
Term loan investment - Armata July 2023 Term Loan		—		—		27,044		27,044
Convertible debt investment - Gate Note		—		—		27,972		27,972
Total assets measured at estimated fair value	$	503,162	$	35,297	$	167,504	$	705,963
Liabilities
Debt
2025 Notes		—		200,407		—		200,407
2028 Notes		—		227,070		—		227,070
Total fair value of debt	$	—	$	427,477	$	—	$	427,477
Contingent value rights		—		—		359		359
Total liabilities at estimated fair value	$	—	$	427,477	$	359	$	427,836

(1)

The investments held by ISP Fund LP, consisted of $248.5 million in equity investments, which included private placement positions of $60.6 million, and $62.9 million in money market funds. A certain portion of the total capital contribution of $300.0 million is no longer subject to a 36-month lock-up period from the date of such capital contribution. However, we did not elect to make a withdrawal in 2023, thereby extending the lock-up period and withdrawal elections into subsequent years.

There were no transfers between Level 1, Level 2 or Level 3 during the periods presented.

The fair values of our equity investments in Armata’s common stock and publicly traded investments held by ISP Fund LP are based on the quoted prices in active markets and are classified as Level 1 financial instruments. The fair values of the warrants in Armata classified within Level 2 are based upon observable inputs that may include benchmark yields, reported trades, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, offers, and reference data including market research publications.

The Gate Convertible Note, the Armata Convertible Note, the Armata July 2023 Term Loan, the Armata March 2024 Term Loan, the InCarda Convertible Note, the InCarda Warrants, the ImaginAb Convertible Note, private placement positions held by ISP Fund LP, and contingent value rights are classified as Level 3 financial instruments as these securities are not publicly traded and the assumptions used in the valuation model for valuing these securities are based on significant unobservable and observable inputs including those of publicly traded peer companies. There are uncertainties on the fair value measurement of the instruments classified under Level 3 due to the use of unobservable inputs and interrelationships between these unobservable inputs, which could result in higher or lower fair value measurements.

The fair values of our 2025 Notes and 2028 Notes are based on recent trading prices of the respective instruments.

Subsequent Event - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Apr. 11, 2024
Subsequent Event [Line Items]
Additional cash investment	$ 0	$ 35,689
Commercial Supply Agreement \| Corden
Subsequent Event [Line Items]
Minimum purchase commitments			$ 30,000

Equity and Other Investments and Fair Value Measurements - Schedule of Income Statement Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Dec. 31, 2023	Mar. 31, 2023	Dec. 31, 2022
Equity Investment
Total revenue	$ 77,499		$ 76,372
Net loss	$ 36,532		$ 34,865
Armata
Equity Investment
Total revenue		$ 1,528		$ 1,051
Loss from operations		(6,578)		(10,328)
Net loss		$ (19,847)		$ (10,314)

- Definition

The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

Net Income Per Share - Anti-Dilutive Securities (Details) - shares shares in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Anti-Dilutive Securities
Anti-dilutive securities (in shares)	1,951	1,917
Equity incentive plans and ESPP
Anti-Dilutive Securities
Anti-dilutive securities (in shares)	1,360	1,326
Outstanding Stock Warrant
Anti-Dilutive Securities
Anti-dilutive securities (in shares)	591	591

Description of Operations and Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2024

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Description of Operations and Summary of Significant Accounting Policies

1. Description of Operations and Summary of Significant Accounting Policies

Description of Operations

Innoviva, Inc. (and where context requires, together with its subsidiaries referred to as “Innoviva”, the “Company”, or “we” and other similar pronouns) is a company with a portfolio of royalties and innovative healthcare assets. Our royalty portfolio contains respiratory assets partnered with Glaxo Group Limited (“GSK”), including RELVAR®/BREO® ELLIPTA® (fluticasone furoate/vilanterol, “FF/VI”) and ANORO® ELLIPTA® (umeclidinium bromide/ vilanterol, “UMEC/VI”). Under the Long-Acting Beta2 Agonist (“LABA”) Collaboration Agreement, Innoviva is entitled to receive royalties from GSK on sales of RELVAR®/BREO® ELLIPTA® as follows: 15% on the first $3.0 billion of annual global net sales and 5% for all annual global net sales above $3.0 billion; and royalties from the sales of ANORO® ELLIPTA®, which tier upward at a range from 6.5% to 10%.

We expanded our portfolio through the acquisition of Entasis Therapeutics Holdings Inc. (“Entasis”) on July 11, 2022 and the acquisition of La Jolla Pharmaceutical Company (“La Jolla”) on August 22, 2022. Our commercial and marketed products include GIAPREZA® (angiotensin II), approved to increase blood pressure in adults with septic or other distributive shock, and XERAVA® (eravacycline) approved for the treatment of complicated intra-abdominal infections in adults. Our third product, XACDURO® (formerly known as sulbactam-durlobactam or SUL-DUR), was approved by the United States Food and Drug Administration (“FDA”) for the treatment of hospital-acquired and ventilator-associated pneumonias caused by Acinetobacter in adults on May 23, 2023. We commenced commercial sales of XACDURO® in the third quarter of 2023. Our development pipeline includes zoliflodacin, an investigational treatment for uncomplicated gonorrhea that reported positive data in a pivotal Phase 3 clinical trial on November 1, 2023. As such, we have a wholly owned robust critical care and infectious disease operating platform with a hospital focus anchored by three differentiated products with growth potential and a late-stage drug candidate.

In addition, we own other strategic healthcare assets, such as a large equity stake in Armata Pharmaceuticals, a leader in development of bacteriophages with potential use across a range of infectious and other serious diseases. We also have economic interests in other healthcare companies.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by U.S. GAAP for complete financial statements. The unaudited condensed consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and, in our opinion, include all adjustments, consisting of all normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending December 31, 2024, or any other periods.

The accompanying unaudited condensed consolidated financial statements include the accounts of Innoviva, our wholly-owned subsidiaries, and certain variable interest entities (“VIEs”) for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2023 filed with the Securities and Exchange Commission (“SEC”) on February 29, 2024, and as amended on March 5, 2024 and March 22, 2024.

Use of Management’s Estimates

The preparation of unaudited condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. Management evaluates its significant accounting policies and estimates on an ongoing basis. We base our estimates on historical experience and other relevant assumptions that we believe to be reasonable under the circumstances. These estimates also form the basis for making judgments about the carrying values of assets and liabilities when these values are not readily apparent from other sources.

Concentrations of Credit Risk and of Significant Suppliers and Partner

Our financial instruments that are exposed to concentrations of credit risk consist primarily of cash and cash equivalents and equity and long-term investments. Although we deposit our cash with multiple financial institutions, our deposits, at times, may exceed federally insured limits.

We are dependent on third-party manufacturers to supply active pharmaceutical ingredients (“API”) and drug products for research and development and commercial programs. These programs could be adversely affected by significant interruption in the supply of API or drug products.

Currently, we derive most of our revenues from GSK. Our near-term success depends in large part upon the performance by GSK of its commercial obligations under the GSK Agreements and the commercial success of RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®. If GSK does not devote sufficient resources to the commercialization of these products, is unsuccessful in its efforts, or chooses to reprioritize its commercial programs, our business would be materially harmed. GSK is responsible for all clinical and other product development, regulatory, manufacturing and commercialization activities for products developed under the GSK Agreements, including RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®. Our quarterly royalty revenues may fluctuate due to a variety of factors, many of which are outside of our control. Our royalty revenues under the GSK Agreements may not meet our analysts’ or investors’ expectations due to a number of important factors.

We also generate revenue from product sales of GIAPREZA® and XERAVA®. Additionally, we generate revenue from product sales of XACDURO®, which was commercially launched in September 2023. In the U.S., hospitals and other healthcare organizations generally acquire our products through a network of specialty distributors, which are regarded as our customers for accounting purposes. We do not believe that the loss of one of these distributors would significantly impact our ability to distribute our products, as we expect that sales volume would be absorbed by either new or remaining distributors. Three of our customers each account for 36%, 26% and 24%, respectively, of our net product sales for the three months ended March 31, 2024. These same customers account for 37%, 21% and 12%, respectively, of our receivables from net product sales, which are included in “Accounts receivables” in our unaudited condensed consolidated balance sheet as of March 31, 2024.

Refer to Item 1A. “Risk Factors” disclosed in our Annual Report on Form 10-K for the year ended December 31, 2023.

Segment Reporting

We operate in a single segment, focusing on providing capital return to stockholders by maximizing the potential value of our portfolio of royalties and innovative healthcare assets. Our Chief Executive Officer serves as our Chief Operating Decision Maker (“CODM”). The CODM allocates resources and evaluates Innoviva’s performance at the consolidated level using information about our revenues, operating results and other key financial data as needed.

Variable Interest Entities

The primary beneficiary of a variable interest entity (“VIE”) is required to consolidate the assets and liabilities of the VIE. When we obtain a variable interest in another entity, we assess at the inception of the relationship and upon occurrence of certain significant events whether the entity is a VIE and, if so, whether we are the primary beneficiary of the VIE based on our power to direct the activities of the VIE that most significantly impact the VIE’s economic performance and our obligation to absorb losses or the right to receive benefits from the VIE that could potentially be significant to the VIE.

To assess whether we have the power to direct the activities of a VIE that most significantly impact the VIE’s economic performance, we consider all the facts and circumstances, including our role in establishing the VIE and our ongoing rights and responsibilities. This assessment includes identifying the activities that most significantly impact the VIE’s economic performance and identifying which party, if any, has power over those activities. In general, the parties that make the most significant decisions affecting the VIE (management and representation on the Board of Directors) and have the right to unilaterally remove those decision-makers are deemed to have the power to direct the activities of a VIE.

To assess whether we have the obligation to absorb losses of the VIE or the right to receive benefits from the VIE that could potentially be significant to the VIE, we consider all of our economic interests that are deemed to be variable interests in the VIE. This assessment requires us to apply judgment in determining whether these interests, in the aggregate, are considered potentially significant to the VIE.

Cash and Cash Equivalents

We consider all highly liquid investments purchased with a maturity of three months or less on the date of purchase to be cash equivalents. Cash equivalents are carried at cost, which approximates fair value.

Accounts Receivable

Accounts receivables are recorded net of estimates for prompt-pay discounts, chargebacks, returns and rebates. Allowances for prompt-pay discounts and chargebacks are based on contractual terms. We estimate the allowance for credit losses based on existing contractual payment terms, actual payment patterns of customers and individual customer circumstances.

Inventory

Inventory is stated at the lower of cost or estimated net realizable value on a first in, first out basis. We periodically analyze inventory levels and write down inventory as cost of products sold when the following occurs: inventory has become obsolete, inventory has a cost basis in excess of its estimated net realizable value, or inventory quantities are in excess of expected product sales.

Goodwill and Intangible Assets

Goodwill is recognized as the excess of the purchase consideration of an acquired entity over the fair value assigned to assets acquired and liabilities assumed in a business combination. Goodwill and intangible assets with an indefinite useful life are not amortized and are tested for impairment at least annually on the first day of December of each year or more frequently if indicators for potential impairment exist or whenever events or changes in circumstances indicate that the asset’s carrying asset amount may not be recoverable. Intangible assets with definite useful lives are amortized on a straight-line basis over their respective remaining useful lives and are tested for impairment only if indicators for potential impairment exist or whenever events or changes in circumstances indicate that the asset’s carrying amount may not be recoverable. Significant judgment may be involved in determining if an indicator of impairment has occurred.

Operating Leases

Right-of-use assets represent our right to use an underlying asset over the lease term and include any lease payments made prior to the lease commencement date and are reduced by lease incentives. Lease liabilities represent the present value of the total lease payments over the lease term, calculated using an estimated incremental borrowing rate. Lease expense is recognized on a straight-line basis over the expected lease term.

Equity and Long-Term Investments

We invest from time to time in equity and debt securities of private or public companies. If we determine that we have control over these companies under either voting or VIE models, we consolidate them in our unaudited condensed consolidated financial statements. If we determine that we do not have control over these companies under either voting or VIE models, we then determine if we have an ability to exercise significant influence via voting interests, board representation or other business relationships.

We may account for the investments where we exercise significant influence using either an equity method of accounting or at fair value by electing the fair value option under Accounting Standards Codification (“ASC”) Topic 825, Financial Instruments. If the fair value option is applied to an investment that would otherwise be accounted for under the equity method, we apply it to all our financial interests in the same entity (equity and debt, including guarantees) that are eligible items. All gains and losses from fair value changes, unrealized and realized, are presented as changes in fair values of equity method investments, net, and changes in fair values of equity and long-term investments, net, within the unaudited condensed consolidated statements of income and comprehensive income.

If we conclude that we do not have an ability to exercise significant influence over an investee, we may elect to account for the security without a readily determinable fair value using the measurement alternative method under ASC 321, Investments - Equity Securities. This measurement alternative method allows us to measure the equity investment at its cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer.

We also invest in ISP Fund LP, which investments consist of money market funds, trading and equity securities in the healthcare, pharmaceutical and biotechnology industries. Pursuant to the Partnership Agreement entered in December 2020, we became a limited partner of this partnership, and our contributions are subject to a 36-month lock-up period which restriction prevents us from having control and access to the contributions and related investments. The lock-up period for a certain portion of our contributions expired in December 2023. We did not elect to make a withdrawal in 2023, thereby extending the lock-up period and withdrawal elections into subsequent years. These investments are classified as long-term investments in the unaudited condensed consolidated balance sheets.

Revenue Recognition

We apply the guidance on principal versus agent considerations under ASC Topic 606, Revenue from Contracts with Customers, to determine the appropriate treatment for the transactions between us and third parties. The classification of transactions under our arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. Any consideration related to activities in which we are considered the principal, which includes being in control of the good or service before such good or service is transferred to the customer, are accounted for as product sales.

Revenue is recognized when our customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. Revenue is recognized through a five-step process: (i) identify the contract with the customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price for the contract; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue as a performance obligation is satisfied.

Royalty Revenue

We recognize the royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. The net sales reports provided by our partner are based on its methodology and assumptions to estimate rebates and returns, which it monitors and adjusts regularly in light of contractual and legal obligations, historical trends, past experience and projected market conditions. Our partner may make significant adjustments to its sales based on actual results recorded, which could cause our royalty revenue to fluctuate. We conduct periodic royalty audits to evaluate the information provided by our partner. Royalties are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK.

Revenue from Product Sales

Revenue from product sales is recognized when our customers obtain control of the product and is recorded at the transaction price, net of estimates for variable consideration consisting of chargebacks, discounts, returns and rebates. Variable consideration is estimated using the expected-value amount method, which is the sum of probability-weighted amounts in a range of possible consideration amounts. Actual amounts of consideration ultimately received may differ from our estimates. If actual results vary materially from our estimates, we will adjust these estimates, which will affect revenue from product sales and earnings in the period such estimates are adjusted. These items may include:

•

Chargebacks: Chargebacks are discounts we provide to distributors in the event that the sales prices to end users are below the distributors’ acquisition price. This may occur due to a direct contract with a health system, a group purchasing organization (“GPO”) agreement or a sale to a government facility. Chargebacks are estimated based on known chargeback rates and recorded as a reduction of revenue on delivery to our customers.

•

Discounts: We offer customers various forms of incentives and consideration, including prompt-pay and other discounts. We estimate discounts primarily based on contractual terms. These discounts are recorded as a reduction of revenue on delivery to our customers.

•

Returns: We offer customers a limited right of return, generally for damaged or expired product. We estimate returns based on an internal analysis, which includes actual experience. The estimates for returns are recorded as a reduction of revenue on delivery to our customers.

•

Rebates: We participate in Medicaid rebate programs, which provide assistance to certain low-income patients based on each individual state’s guidelines regarding eligibility and services. Under the Medicaid rebate programs, we pay a rebate to each participating state, generally within three months after the quarter in which product was sold. Additionally, we may offer customer incentives and consideration in the form of volume-based or other rebates. The estimates for rebates are recorded as a reduction of revenue on delivery to our customers.

We continue to assess our estimates of variable consideration as we accumulate additional historical data and will adjust these estimates accordingly.

License Revenue

At the inception of a licensing arrangement that includes development and regulatory milestone payments, we evaluate whether the milestones are considered probable of being achieved and estimate the amount to be included in the transaction price. We generally include these milestone payments in the transaction price when they are achieved because there is considerable uncertainty in the research and development processes that trigger receipt of these payments under our agreements. Similarly, we include approval milestone payments in the transaction price once the product is approved by the applicable regulatory agency.

Research and Development Expenses

Research and development expenses are recognized in the period that services are rendered or goods are received. Research and development expenses consist of salaries and benefits, laboratory supplies, facilities and other overhead costs, research-related manufacturing costs, contract service and clinical-related service costs performed by third party research organizations, research institutions and other outside service providers. Non-refundable prepayments for goods or services that will be used or rendered for future research and development activities are deferred and capitalized. Such amounts are recognized as an expense as the related goods are delivered or the related services are performed. We also utilize significant judgment and estimates to record accruals for estimated ongoing research costs based on the progress of the studies and progress of research manufacturing activities.

Interest Expense on Deferred Royalty Obligation

Interest expense related to the deferred royalty obligation is recognized over the expected repayment term of the deferred royalty obligation using the effective interest method. The assumptions used in determining the expected repayment term of the deferred royalty obligation require us to make estimates that could impact the effective interest rate. Each reporting period, we estimate the expected repayment term of the deferred royalty obligation based on forecasted net sales of GIAPREZA®. Changes in interest expense resulting from changes in the effective interest rate, if any, are recorded on a prospective basis. Refer to Note 11, “Debt” for more information.

Related Party

Sarissa Capital owned 11.6% of our outstanding common stock as of March 31, 2024. Transactions with Sarissa Capital are described in Note 5, “Consolidated Entity”. Sarissa Capital is considered to be a related party because two of its principals are members of our board of directors.

Recently Issued Accounting Pronouncements Not Yet Adopted

In October 2023, the Financial Accounting Standards Board (“FASB”) issued ASU 2023-06, Disclosure Improvements: Codification Amendments in Response to the SEC’s Disclosure Update and Simplification Initiative. The amendment modifies the disclosure or presentation requirements for a variety of topics. The effective date for each amendment will be the date on which the SEC’s removal of that related disclosure from Regulation S-X or Regulation S-K becomes effective. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements.

In November 2023, the FASB issued ASU 2023-07, Improvements to Reportable Segment Disclosures (Topic 280). This ASU update requires enhanced segment disclosures, primarily related to significant segment expenses. The amendments are effective for fiscal years beginning after December 15, 2023, and interim periods beginning after December 15, 2024. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements.

In December 2023, the FASB issued ASU 2023-09, Improvements to Income Tax Disclosures (Topic 740). The ASU requires the disclosure of income taxes paid disaggregated by jurisdiction and enhanced disclosures for the entity’s effective tax rate reconciliation as well as other income tax related disclosures. The ASU is effective on a prospective basis for annual periods beginning after December 15, 2024. The Company does not expect the adoption of the amendments to have a significant impact on its financial statements.

License and Collaboration Arrangements

3 Months Ended

Mar. 31, 2024

Organization, Consolidation and Presentation of Financial Statements [Abstract]

License and Collaboration Arrangements

4. License and Collaboration Arrangements

Out-License Agreements

Zai Lab

Entasis entered into a license and collaboration agreement with Zai Lab (Shanghai) Co., Ltd. (“Zai Lab”) (Nasdaq: ZLAB), pursuant to which Zai Lab licensed exclusive rights to durlobactam and SUL-DUR, in the Asia-Pacific region (“the Zai Agreement”). Under the terms of the Zai Agreement, Zai Lab will fund most of the registrational clinical trial costs in China for SUL-DUR, with the exception of Phase 3 patient drug supply of licensed products. Zai Lab will conduct development activities and plan and obtain regulatory approval in a specified number of countries in the Asia-Pacific region beyond China after receipt of regulatory approval of a licensed product in China. Zai Lab is also solely responsible for commercializing licensed products in the Asia-Pacific region and will commercialize licensed products for which it has obtained regulatory approval. We are obligated to supply Zai Lab with the licensed products for clinical development and, if the licensed product is approved, for commercial use for a certain period unless Zai Lab notifies otherwise. Zai Lab may take over manufacturing responsibilities for its own commercialization activities within a specified time period following the effective date of the Zai Agreement.

We are eligible to receive up to an aggregate of $91.0 million in research and development support payments and development, regulatory and sales milestone payments related to SUL-DUR, imipenem and other combinations with the licensed products. Zai Lab will pay us a tiered royalty equal to from a high-single digit to low-double digit percentage based on annual net sales of licensed products in the territory, subject to specified reductions for the market entry of competing products, loss of patent coverage of licensed products and for payments owed to third parties for additional rights necessary to commercialize licensed products in the territory. Payments received for research support and reimbursable clinical trial costs are recorded as a reduction to research and development expense during the period in which the qualifying expenses are incurred. Such amounts recorded for the three months ended March 31, 2024 and 2023 were not material.

On April 24, 2024, we entered into an amendment to the Zai Agreement, pursuant to which Zai Lab shall share certain costs estimated at approximately $8.1 million associated with supply chain activities for manufacturing XACDURO®.

GARDP

Entasis entered into a collaboration agreement with the Global Antibiotic Research and Development Partnership (“GARDP”) for the development, manufacture and commercialization of the product candidate zoliflodacin in certain countries (“the GARDP Collaboration Agreement”). Under the terms of the GARDP Collaboration Agreement, GARDP will use commercially reasonable endeavors to perform and fully fund the Phase 3 registrational trial, including the manufacture and supply of the product candidate containing zoliflodacin, in uncomplicated gonorrhea. We recorded reimbursements from GARDP under this agreement as reduction to research and development expense. Relevant amounts for the three months ended March 31, 2024 and 2023 were not material.

In addition, under the GARDP Collaboration Agreement, GARDP was granted a worldwide, fully paid, exclusive and royalty-free license, with the right to sublicense, to use our zoliflodacin technology in connection with GARDP’s development, manufacture and commercialization of zoliflodacin in low-income and specified middle-income countries. We retained commercial rights in all other countries worldwide, including the major markets in North America, Europe and Asia-Pacific. We also retained the right to use and grant licenses to our zoliflodacin technology to perform our obligations under the GARDP Collaboration Agreement and for any purpose other than gonorrhea or community-acquired indications. If we believe that the results of the Phase 3 registrational trial of zoliflodacin would be supportive of an application for marketing approval, we are obligated to use our best efforts to file an application for marketing approval with the FDA within six months of the completion of the trial and to use commercially reasonable endeavors to file an application for marketing approval with the European Medicines Agency (“EMA”). Each party is responsible for using commercially reasonable efforts to obtain marketing authorizations for the product candidate in their respective territories.

PAION Pharma GmbH

Pursuant to the PAION AG and PAION Deutschland GmbH (together and individually “PAION”) License, La Jolla granted PAION an exclusive license to commercialize GIAPREZA® and XERAVA® in the European Economic Area, the United Kingdom and Switzerland (collectively, the “PAION Territory”). We are entitled to receive potential commercial milestone payments of up to $109.5 million and double-digit tiered royalty payments. Royalties payable in a given jurisdiction under the PAION License will be subject to reduction on account of generic competition and after patent expiration in that jurisdiction. Pursuant to the PAION License, PAION will be solely responsible for the future development and commercialization of GIAPREZA® and XERAVA® in the PAION Territory. PAION is required to use commercially reasonable efforts to commercialize GIAPREZA® and XERAVA® in the PAION Territory. We have not recognized any revenue from PAION related to commercial milestones from the date of acquisition of La Jolla to March 31, 2024. Royalty revenue recognized under this agreement for the three months ended March 31, 2024 and 2023 was not material.

La Jolla also entered into the PAION commercial supply agreement (the “PAION Supply Agreement”) whereby La Jolla will supply PAION a minimum quantity of GIAPREZA® and XERAVA® through July 13, 2024. The PAION supply agreement will automatically renew until the earlier of July 13, 2027, or until a new supply agreement is executed. During the initial term of the supply agreement, we will be reimbursed for direct and certain indirect manufacturing costs at cost. We did not recognize any cost reimbursements under this agreement for the three months ended March 31, 2024 and 2023.

PAION filed for insolvency in Germany on October 27, 2023 and the insolvency proceedings commenced on January 1, 2024. PAION announced on December 22, 2023 that it concluded negotiations with Humanwell Healthcare Group and entered into an agreement on the sale of the essential business operations of PAION with the approval of the insolvency administrator in both procedures. In early 2024, the sale of business operations of PAION was completed and starting February 2024, PAION has continued its business as a subsidiary of the Humanwell Healthcare Group as an independent company under the name PAION Pharma GmbH.

Everest Medicines Limited

Pursuant to the Everest Medicines Limited (“Everest”) License, La Jolla granted Everest an exclusive license to develop and commercialize XERAVA® for the treatment of complicated intra-abdominal infections (“cIAI”) and other indications in mainland China, Taiwan, Hong Kong, Macau, South Korea, Singapore, the Malaysian Federation, the Kingdom of Thailand, the Republic of Indonesia, the Socialist Republic of Vietnam and the Republic of the Philippines (collectively, the “Everest Territory”). Under the Everest License, we recognized $8.0 million in license revenue for the three months ended March 31, 2023 as a result of our achievement of a regulatory milestone during the period. We are eligible to receive additional sales milestone payments of up to an aggregate of $20.0 million.

We are also entitled to receive tiered royalties from Everest at percentages in the low double digits on sales, if any, in the Everest Territory of products containing eravacycline. Royalties are payable with respect to each jurisdiction in the Everest Territory until the latest to occur of: (i) the last-to-expire of specified patent rights in such jurisdiction in the Everest Territory; (ii) expiration of marketing or regulatory exclusivity in such jurisdiction in the Everest Territory; or (iii) 10 years after the first commercial sale of a product in such jurisdiction in the Everest Territory. Royalty revenue recognized for the three months ended March 31, 2024 and 2023 was not material.

La Jolla also entered into the Everest commercial supply agreement (the “Everest Supply Agreement”) whereby La Jolla will supply Everest a minimum quantity of XERAVA® and will transfer to Everest certain XERAVA®-related manufacturing know-how. Under the Everest Supply Agreement, we are reimbursed for direct and certain indirect manufacturing costs at 110% of cost. Revenue recognized under this agreement for the three months ended March 31, 2024 and 2023 was not material.

In-License Agreements

George Washington University

Pursuant to the George Washington University (“GW”) License, GW exclusively licensed to La Jolla certain intellectual property rights relating to GIAPREZA®, including the exclusive rights to certain issued patents and patent applications covering GIAPREZA®. Under the GW License, we are obligated to use commercially reasonable efforts to develop, commercialize, market and sell GIAPREZA®. We are obligated to pay a 6% royalty on net sales of GIAPREZA® and 15% on payments received from sublicensees. The obligation to pay royalties under this agreement extends through the last-to-expire patent covering GIAPREZA®. Amounts recognized under this agreement for the three months ended March 31, 2024 and 2023 were not material.

Harvard University

Pursuant to the Harvard University (“Harvard”) License, Harvard exclusively licensed to La Jolla certain intellectual property rights relating to tetracycline-based products, including XERAVA®, including the exclusive rights to certain issued patents and patent applications covering such products. Under the Harvard License, we are obligated to use commercially reasonable efforts to develop, commercialize, market and sell tetracycline-based products, including XERAVA®. For each product covered by the Harvard License, we are obligated to make certain payments for the following: (i) up to approximately $15.1 million upon the achievement of certain clinical development and regulatory milestones; (ii) a 5% royalty on direct U.S. net sales of XERAVA®; (iii) a single-digit tiered royalty on direct ex-U.S. net sales of XERAVA®, starting at a minimum royalty rate of 4.5%, with step-ups to a maximum royalty of 7.5% based on the achievement of annual net product sales thresholds; and (iv) 20% on payments received from sublicensees. The obligation to pay royalties under this agreement extends through the last-to-expire patent covering tetracycline-based products, including XERAVA®. Amounts recognized under this agreement for the three months ended March 31, 2024 were not material. For the three months ended March 31, 2023, we recognized $1.6 million in cost of license revenue under this agreement as a result of the license revenue we earned under the out-licensing agreement with Everest for the same period.

Paratek Pharmaceuticals, Inc.

Pursuant to the Paratek Pharmaceuticals, Inc. (“Paratek”) License, Paratek non-exclusively licensed to La Jolla certain intellectual property rights relating to XERAVA®, including non-exclusive rights to certain issued patents and patent applications covering XERAVA®. We are obligated to pay Paratek a 2.25% royalty based on direct U.S. net sales of XERAVA®. Our obligation to pay royalties with respect to the licensed product was retroactive to the date of the first commercial sale of XERAVA® and continued until there were no longer any valid claims of the Paratek patents, which expired in October 2023. Amounts recognized under this agreement for the three months ended March 31, 2023 were not material.

Business Transfer and Subscription Agreement with AstraZeneca

Entasis entered into a Business Transfer and Subscription Agreement with AstraZeneca, AstraZeneca UK Limited and AstraZeneca Pharmaceuticals LP (collectively, “AstraZeneca”) (the “AstraZeneca Agreement”) in 2015, which was amended and restated through 2018, pursuant to which Entasis obtained, among other things, worldwide rights to durlobactam and zoliflodacin. Under the AstraZeneca Agreement, we are obligated to pay AstraZeneca a one-time milestone payment of $5.0 million within three months of achieving a specified cumulative net sales milestone for durlobactam. We are also obligated to pay AstraZeneca a one-time milestone payment of $10.0 million within two years of achieving the first commercial sale of zoliflodacin. Additionally, we are obligated to pay AstraZeneca tiered, single-digit royalties on the annual worldwide net sales of durlobactam and, the lesser of tiered, single-digit royalties on the worldwide annual net sales of zoliflodacin and a specified share of the royalties we receive from sublicensees of zoliflodacin. Royalties on sales of zoliflodacin do not include sales by GARDP in low-income and specified middle-income countries as discussed above. Our obligation to make these royalty payments expires with respect to each product on a country-by-country basis upon the later of (i) the 10-year anniversary of the first commercial sale of a product in each such country or (ii) when the last patent right covering a product expires in each such country.

The royalty expense in respect of durlobactam arising from our net sales of XACDURO® for the three months ended March 31, 2024 was not material.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) - USD ($) shares in Thousands, $ in Thousands	Total	Common stock	Additional Paid-In Capital	Retained Earnings (Accumulated Deficit)	Treasury Stock
Balance at Dec. 31, 2022	$ 565,788	$ 692	$ 1,163,836	$ (204,911)	$ (393,829)
Balance (in shares) at Dec. 31, 2022		69,188			32,005
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	(23)	$ 1	(24)	0	$ 0
Exercise of stock options and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding		55			0
Repurchase of common stock	(40,735)	$ (34)	(40,701)	0	$ 0
Repurchase of common stock (in shares)		(3,419)			0
Stock-based compensation	1,598	$ 0	1,598	0	$ 0
Stock-based compensation (in shares)		0			0
Net income	34,865	$ 0	0	34,865	$ 0
Net Income (Shares)		0			0
Balance at Mar. 31, 2023	561,493	$ 659	1,124,709	(170,046)	$ (393,829)
Balance (in shares) at Mar. 31, 2023		65,824			32,005
Balance at Dec. 31, 2023	$ 674,955	$ 633	1,093,340	(25,189)	$ (393,829)
Balance (in shares) at Dec. 31, 2023	63,307	63,307			32,005
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	$ 404	$ 1	403	0	$ 0
Exercise of stock options and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding		124			0
Repurchase of common stock	(9,665)	$ (6)	(9,659)		$ 0
Repurchase of common stock (in shares)		(634)			0
Stock-based compensation	1,455	$ 0	1,455	0	$ 0
Stock-based compensation (in shares)		0			0
Net income	36,532	$ 0	0	36,532	$ 0
Net Income (Shares)		0			0
Balance at Mar. 31, 2024	$ 703,681	$ 628	$ 1,085,539	$ 11,343	$ (393,829)
Balance (in shares) at Mar. 31, 2024	62,797	62,797			32,005

Goodwill and Intangible Assets (Tables)

3 Months Ended

Mar. 31, 2024

Goodwill and Intangible Assets Disclosure [Abstract]

Summary of Accumulated Amortization of Recognized Intangible Assets

The carrying basis and accumulated amortization of recognized intangible assets as of March 31, 2024 and December 31, 2023 were as follows:


	March 31, 2024
	Useful Life	Gross		Accumulated			Net Carrying
(In thousands)	(Years)	Amount		Amortization			Amount
Marketed products	8-10	$	219,700	$	(30,763	)	$	188,937
In-process research and development			2,600		—		$	2,600
Collaboration agreement	10		35,400		(3,042	)	$	32,358
Total		$	257,700	$	(33,805	)	$	223,895


	December 31, 2023
	Useful Life	Gross		Accumulated			Net Carrying
(In thousands)	(Years)	Amount		Amortization			Amount
Marketed products	8-10	$	219,700	$	(25,204	)	$	194,496
In-process research and development			2,600		—			2,600
Collaboration agreement	10		35,400		(2,161	)		33,239
Total		$	257,700	$	(27,365	)	$	230,335

Balance Sheet Components (Tables)

3 Months Ended

Mar. 31, 2024

Balance Sheet Related Disclosures [Abstract]

Schedule of Inventory

Inventory consisted of the following:


	March 31,		December 31,
(in thousands)	2024		2023
Raw materials	$	9,525	$	11,257
Work-in-process		20,196		15,670
Finished goods		7,716		13,810
Total inventory	$	37,437	$	40,737

Schedule Of Other Accrued Liabilities

Other accrued liabilities consisted of the following:


	March 31,		December 31,
(in thousands)	2024		2023
Accrued contract manufacturing expenses	$	2,197	$	1,966
Accrued clinical and research expenses		554		776
Accrued professional services		10,936		8,876
Current portion of lease liabilities		1,268		1,207
Royalty obligation payable		2,531		1,928
Accrued license fees and royalties		1,136		1,575
Other		5,125		3,370
Total other accrued liabilities	$	23,747	$	19,698

Schedule of Other Long-term Liabilities

Other long-term liabilities consisted of the following:


	March 31,		December 31,
(in thousands)	2024		2023
Long-term portion of deferred royalty obligation	$	70,057	$	69,876
Long-term portion of lease liabilities		1,304	$	1,635
Contingent value rights liability		325		359
Total other long-term liabilities	$	71,686	$	71,870

License and Collaboration Arrangements (Additional Information) (Details) - USD ($) $ in Thousands		3 Months Ended
	Apr. 24, 2024	Mar. 31, 2024	Mar. 31, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenue		$ 77,499	$ 76,372
Zai Lab \| Subsequent Event
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cost incurred for supply chain activities	$ 8,100
Zai Lab \| Research and Development Support
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Future potential milestone payment receivable		91,000
PAION AG
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Future potential milestone payment receivable		109,500
PAION AG \| Cost Reimbursement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenues		0	0
Everest Medicines Limited
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sales milestone payments receivable		$ 20,000
License revenue recognized			8,000
Royalties payable period after first commercial sale of product		10 years
Everest Medicines Limited \| Commercial Supply Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of reimbursed for direct and certain indirect manufacturing costs		110.00%
George Washington University
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of royalty payable on net sales		6.00%
Percentage of royalty on payments received from sublicensees		15.00%
Harvard University
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of royalty payable on net sales		5.00%
Percentage of royalty on payments received from sublicensees		20.00%
Cost of license revenue			$ 1,600
Clinical development and regulatory milestones amount payable		$ 15,100
Percentage of minimum royalty rate		4.50%
Percentage of maximum royalty based on achievement of annual net product sales thresholds		7.50%
Paratek Pharmaceuticals, Inc.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of royalty payable on net sales		2.25%
Claim expiration		2023-10
Astrazeneca
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
One-time Milestone Payment on Net Sales		$ 5,000
Term of Milestone Payment for Net Sales		3 months
One-time Milestone Payment on Commercial Sales		$ 10,000
Term of Milestone Payment for Commercial Sale		2 years

Consolidated Entities and Acquisitions - Schedule of Recognized Identified Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023	Aug. 22, 2022	Jul. 11, 2022
Business Acquisition [Line Items]
Goodwill	$ 17,905	$ 17,905
La Jolla Pharmaceutical Company
Business Acquisition [Line Items]
Goodwill			$ 6,400
Intangible assets	151,000
Entasis Therapeutics Holdings Inc
Business Acquisition [Line Items]
Goodwill				$ 11,500
Intangible assets	$ 106,700

- Definition

Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.

+ References + Details

CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND COMPREHENSIVE INCOME (Parenthetical) (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Royalty revenue \| GSK
Amortization of capitalized fees paid	$ 3,456	$ 3,456

Description of Operations and Summary of Significant Accounting Policies (Details) $ in Billions	3 Months Ended
	Mar. 31, 2024 USD ($) Customer
Description of Operations and Summary of Significant Accounting Policies
Number of customers \| Customer	3
Customer Concentration Risk \| Net Product Sales \| La Jolla [Member] \| Customer One
Description of Operations and Summary of Significant Accounting Policies
Concentration Risk, Percentage	36.00%
Customer Concentration Risk \| Net Product Sales \| La Jolla [Member] \| Customer Two
Description of Operations and Summary of Significant Accounting Policies
Concentration Risk, Percentage	26.00%
Customer Concentration Risk \| Net Product Sales \| La Jolla [Member] \| Customer Three
Description of Operations and Summary of Significant Accounting Policies
Concentration Risk, Percentage	24.00%
Customer Concentration Risk \| Receivables from Net Product Sales \| La Jolla [Member] \| Customer One
Description of Operations and Summary of Significant Accounting Policies
Concentration Risk, Percentage	37.00%
Customer Concentration Risk \| Receivables from Net Product Sales \| La Jolla [Member] \| Customer Two
Description of Operations and Summary of Significant Accounting Policies
Concentration Risk, Percentage	21.00%
Customer Concentration Risk \| Receivables from Net Product Sales \| La Jolla [Member] \| Customer Three
Description of Operations and Summary of Significant Accounting Policies
Concentration Risk, Percentage	12.00%
Sarissa Capital
Description of Operations and Summary of Significant Accounting Policies
Percentage of common stock owned by a related party	11.60%
Long-Acting Beta2 Agonist (LABA) Collaboration \| GSK \| RELVAR/BREO
Description of Operations and Summary of Significant Accounting Policies
Royalty rate for first level of annual global net sales (as a percent)	15.00%
Annual global sales level used to determine royalty rate \| $	$ 3.0
Royalty rate for sales above first level of annual global net sales (as a percent)	5.00%
Long-Acting Beta2 Agonist (LABA) Collaboration \| GSK \| ANORO \| Minimum
Description of Operations and Summary of Significant Accounting Policies
Royalty rate for combination products (as a percent)	6.50%
Long-Acting Beta2 Agonist (LABA) Collaboration \| GSK \| ANORO \| Maximum
Description of Operations and Summary of Significant Accounting Policies
Royalty rate for combination products (as a percent)	10.00%

Stockholders' Equity

3 Months Ended

Mar. 31, 2024

Equity [Abstract]

Stockholders' Equity

10. Stockholders' Equity

On October 31, 2022, our board of directors authorized a new share repurchase program under which we may repurchase up to $100.0 million of our outstanding shares of common stock. The repurchase program authorizes the repurchase by the Company of its common stock in open market transactions, including pursuant to a trading plan in accordance with Rule 10b-18 promulgated under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), privately negotiated transactions, in block trades, accelerated share repurchase transactions, exchange transactions, or any combination thereof or by other means in accordance with federal securities laws. The authorization permits management to repurchase shares of the Company’s common stock from time to time at management’s discretion. Repurchases may also be made pursuant to a trading plan under Rule 10b5-1 under the Exchange Act, which would permit shares to be repurchased when the Company might otherwise be precluded from doing so because of self-imposed trading blackout periods or other regulatory restrictions. The actual means and timing of any shares purchased under the program will depend on a variety of factors, including ongoing assessments of the capital needs of the business, the market price of our common stock, prevailing stock prices, general market conditions and other considerations. This program has no termination date, may be suspended or discontinued at any time at our discretion, and does not obligate us to acquire any amount of common stock. For the three months ended March 31, 2024, we have repurchased 634,107 shares in the open market at an average price of $15.24 per share for a total amount of approximately $9.7 million. All the repurchased shares were retired. Subsequent to March 31, 2024 and through April 25, 2024, we completed the program by repurchasing 352,821 shares in the open market at an average price of $14.91 per share for a total amount of approximately $5.3 million.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 505
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481004/946-505-50-6

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480237/815-40-50-6

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480008/505-10-S99-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(e)(1))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (g)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Section 50
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
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-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
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-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

+ Details

Debt - Convertible Senior Notes (Details) $ / shares in Units, $ in Thousands		3 Months Ended
	Aug. 07, 2017 USD ($) $ / shares	Mar. 31, 2024 USD ($)	Mar. 31, 2023 USD ($)	Mar. 31, 2022 USD ($) $ / shares $ / Item	Dec. 31, 2023 USD ($)	Aug. 01, 2017 $ / shares	Jan. 31, 2013 USD ($)
Debt
Payment for repurchase of debt instrument		$ 0	$ 96,204
Debt discount and issuance costs, net		(6,741)			$ (7,266)
2023 Notes
Debt
Loan amount		$ 96,200
2025 Notes
Debt
Common stock price to current conversion price ratio		130.00%
Average trading price percentage		98.00%
2025 Notes \| Common stock
Debt
Share Price \| $ / shares						$ 13.28
2028 Notes
Debt
Debt instrument, covenant terms description		The indenture governing the 2028 Notes contains customary terms and covenants, including a merger covenant and that upon certain events of default occurring and continuing, either the Trustee or the holders of at least 25% of the aggregate principal amount of the outstanding Notes may declare 100% of the principal of, and accrued and unpaid interest, if any, on, all the Notes to be due and payable immediately.
Convertible senior notes \| 2025 Notes
Debt
Ratio of repurchase price to the principal amount		100.00%
Effective interest rate		2.88%
Principal		$ 192,500			192,500
Debt discount and issuance costs, net		(1,024)			(1,205)
Net carrying amount		191,476			191,295
Interest expense
Contractual interest expense		1,203	1,203
Amortization of debt issuance costs		181	176
Total interest and amortization expense		$ 1,384	1,379
Convertible senior notes \| 2025 Notes \| Over-Allotment Option
Debt
Loan amount	$ 17,500
Portion of debt instrument face amount, Exercised	17,500
Convertible senior notes \| 2025 Notes \| Private Placement
Debt
Loan amount	$ 192,500
Debt Instrument, annual interest rate	2.50%
Convertible senior notes \| 2025 Notes \| Common stock
Debt
Conversion rate for shares of common stock per $1,000 principal	57.924
Conversion price (dollars per share) \| $ / shares	$ 17.26
Debt instrument maturity date	Aug. 15, 2025
Conversion premium (as a percent)	30.00%
Convertible senior notes \| 2028 Notes
Debt
Loan amount				$ 261,000
Debt instrument maturity date				Mar. 15, 2028
Proceeds from issuance of convertible notes, net of issuance costs				$ 252,600
Common stock price to current conversion price ratio				130.00%
Average trading price percentage				98.00%
Ratio of repurchase price to the principal amount				100.00%
Effective interest rate		2.70%
Principal		$ 261,000			261,000
Debt discount and issuance costs, net		(5,717)			(6,061)
Net carrying amount		255,283			$ 254,939
Interest expense
Contractual interest expense		1,387	1,387
Amortization of debt issuance costs		344	335
Total interest and amortization expense		$ 1,731	$ 1,722
Convertible senior notes \| 2028 Notes \| Privately-negotiated capped call option
Debt
Cap price for the underlying number of shares (in dollars per share) \| $ / Item				33.985
Purchases of capped calls in connection with convertible senior notes due 2028				$ 21,000
Convertible senior notes \| 2028 Notes \| Over-Allotment Option
Debt
Loan amount				45,000
Portion of debt instrument face amount, Exercised				$ 36,000
Convertible senior notes \| 2028 Notes \| Private Placement
Debt
Debt Instrument, annual interest rate				2.125%
Convertible senior notes \| 2028 Notes \| Common stock
Debt
Conversion rate for shares of common stock per $1,000 principal				38.1432
Conversion price (dollars per share) \| $ / shares				$ 26.22
Convertible subordinated notes \| 2023 Notes
Debt
Loan amount							$ 287,500
Debt Instrument, Repurchased Face Amount				$ 144,800
Payment for repurchase of debt instrument				$ 165,600

Debt - Convertible Subordinated Notes (Details) - 2023 Notes - USD ($) $ in Millions	Mar. 31, 2024	Jan. 31, 2013
Debt
Loan amount	$ 96.2
Convertible subordinated notes
Debt
Loan amount		$ 287.5

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Equity and Other Investments and Fair Value Measurements - Equity Investment in InCarda (Details) $ / shares in Units, $ in Thousands			3 Months Ended
	Jun. 15, 2022 USD ($) $ / shares shares	Mar. 09, 2022 USD ($)	Mar. 31, 2024 USD ($) Director	Jun. 30, 2023 USD ($)	Mar. 31, 2023 USD ($)	Jun. 30, 2022 USD ($)	Sep. 30, 2020 USD ($) shares	Jan. 17, 2024 USD ($)	Dec. 31, 2023 USD ($)
Equity Investment
Total purchase price			$ 453,500						$ 453,500
InCarda
Equity Investment
Number of Investee's Board members currently representing the Company \| Director			6
Carrying value wrote off warrant exercise					$ 100
Unrealized loss from fair value changes in equity investments					$ 100
Consolidated Investees [Member] \| InCarda
Equity Investment
Equity investment ownership percentage			8.10%						8.10%
InCarda Convertible Note \| InCarda
Equity Investment
Equity and long-term investments at fair value			$ 400
Total purchase price								$ 400
Debt Instrument, annual interest rate								8.00%
Series C preferred stock and warrants \| InCarda
Equity Investment
Amount of securities purchase agreement							$ 15,800
Warrants \| InCarda
Equity Investment
Maximum number of additional shares into which warrants may be converted under the securities purchase agreement \| shares							5,117,358
Extended expiration date					Mar. 31, 2023
Convertible note and warrants \| InCarda
Equity Investment
Amount of securities purchase agreement		$ 700
Common stock \| InCarda
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued \| shares	4,093,886
Series A1 preferred stock \| InCarda
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued \| shares	37,350
Series D 1 Preferred Stock \| InCarda
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued \| shares	8,771,780
Series D 2 Preferred Stock \| InCarda
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued \| shares	3,369,802
Series D1 Warrant \| InCarda
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued \| shares	2,490,033
Exercise price of warrants \| $ / shares	$ 0.2
Series C preferred stock \| InCarda
Equity Investment
Number of shares to be purchased under the securities purchase agreement \| shares							20,469,432
Debt Conversion, Converted Instrument, Shares Issued \| shares	5,117,358
Transaction cost							$ 800
Equity and long-term investments at fair value			4,800						$ 4,800
Impairment of equity investments				$ 2,900		$ 9,000
Exercise price of warrants \| $ / shares	$ 0.73
Series D warrants \| InCarda
Equity Investment
Equity and long-term investments at fair value			100						100
Series D Preferred Stock \| InCarda
Equity Investment
Payments to acquire equity securities	$ 2,300
Series D 1 And D 2 Preferred Stock And Common Stock \| InCarda
Equity Investment
Equity and long-term investments at fair value			$ 2,700						$ 2,700
Significant Unobservable Inputs, Level 3 \| Backsolve Valuation \| InCarda
Equity Investment
Expected holding period			2 years			2 years
Risk free interest rate			4.90%			3.20%
Dividend yield			0.00%			0.00%
Estimated volatility			114.20%			122.00%

Revenue Recognition

3 Months Ended

Mar. 31, 2024

Revenue from Contract with Customer [Abstract]

Revenue Recognition

3. Revenue Recognition

Net Revenue from Collaboration Arrangement

Net revenue recognized under our GSK Agreements was as follows:


	Three Months Ended March 31,
(In thousands)	2024			2023
Royalties - RELVAR/BREO	$	52,138		$	50,883
Royalties - ANORO		9,733			9,431
Total royalties		61,871			60,314
Less: amortization of capitalized fees paid		(3,456	)		(3,456	)
Total net royalty revenue	$	58,415		$	56,858

Net Product Sales

Our net product sales were $19.1 million, consisting of net sales of GIAPREZA®, XERAVA®, and XACDURO® for $12.1 million, $4.8 million and $2.2 million, respectively, for the three months ended March 31, 2024. We derived over 91% of our net product sales from customers located in the U.S for the period.

Our net product sales were $11.5 million, consisting of net sales of GIAPREZA® and XERAVA® for $9.0 million and $2.5 million, respectively, for the three months ended March 31, 2023. We derived over 99% of our net product sales from customers located in the U.S for the period.

License Revenue

Refer to the out-license agreement with Everest in Note 4, “License and Collaboration Arrangements”.

- Definition

The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-9

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-10

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Name Accounting Standards Codification
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-URI https://asc.fasb.org//606/tableOfContent

+ Details

Equity and Other Investments and Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2024

Financial Instruments and Fair Value Measurements

Schedule of Amortized Cost and Estimated Fair Values for Available-for-Sale Securities


	March 31, 2024
			Gross		Gross
	Amortized		Unrealized		Unrealized		Estimated
(In thousands)	Cost		Gains		Losses		Fair Value
Money market funds(1)	$	151,836	$	—	$	—	$	151,836
Total	$	151,836	$	—	$	—	$	151,836

(1) Money market funds are included in cash and cash equivalents in the condensed consolidated balance sheets.


	December 31, 2023
			Gross		Gross
	Amortized		Unrealized		Unrealized		Estimated
(In thousands)	Cost		Gains		Losses		Fair Value
Money market funds (1)	$	170,706	$	—	$	—	$	170,706
Total	$	170,706	$	—	$	—	$	170,706

(1) Money market funds are included in cash and cash equivalents in the condensed consolidated balance sheets.

Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis

Our available-for-sale securities, equity and long-term investments and contingent value rights are measured at fair value on a recurring basis and our debt is carried at amortized cost basis.


	Estimated Fair Value Measurements as of March 31, 2024 Using:
	Quoted Price in Active Markets for		Significant Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	151,836	$	—	$	—	$	151,836
Investments held by ISP Fund LP (1)		225,521		—		61,618		287,139
Equity investment - Armata Common Stock		104,821		—		—		104,821
Equity investment - Armata Warrants		—		47,067		—		47,067
Equity investment - InCarda Warrants		—		—		75		75
Convertible debt investment - Armata Note		—		—		64,254		64,254
Term loan investment - Armata July 2023 Term Loan		—		—		27,426		27,426
Term loan investment - Armata March 2024 Term Loan		—		—		35,479		35,479
Convertible debt investment - InCarda Note		—		—		436		436
Convertible debt investment - ImaginAb Note		—		—		2,894		2,894
Convertible debt investment - Gate Note		—		—		33,201		33,201
Total assets measured at estimated fair value	$	482,178	$	47,067	$	225,383	$	754,628
Liabilities
Debt
2025 Notes	$	—	$	205,325	$	—	$	205,325
2028 Notes		—		230,333		—		230,333
Total fair value of debt	$	—	$	435,658	$	—	$	435,658
Contingent value rights		—		—		325		325
Total liabilities measured at estimated fair value	$	—	$	435,658	$	325	$	435,983

(1)


	Estimated Fair Value Measurements as of December 31, 2023 Using:
	Quoted Price
	in Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	170,706	$	—	$	—	$	170,706
Investments held by ISP Fund LP (1)		251,207		—		60,605		311,812
Equity investment - Armata Common Stock		81,249		—		—		81,249
Equity investment - Armata Warrants		—		35,297		—		35,297
Convertible debt investment - Armata Note						51,883		51,883
Term loan investment - Armata July 2023 Term Loan		—		—		27,044		27,044
Convertible debt investment - Gate Note		—		—		27,972		27,972
Total assets measured at estimated fair value	$	503,162	$	35,297	$	167,504	$	705,963
Liabilities
Debt
2025 Notes		—		200,407		—		200,407
2028 Notes		—		227,070		—		227,070
Total fair value of debt	$	—	$	427,477	$	—	$	427,477
Contingent value rights		—		—		359		359
Total liabilities at estimated fair value	$	—	$	427,477	$	359	$	427,836

(1)

Armata

Financial Instruments and Fair Value Measurements

Schedule of Income Statements of VIE

The summarized financial information, including the portion we do not own, is presented for Armata on a one quarter lag as follows:

Income Statement Information


	Three Months Ended December 31,
(In thousands)	2023			2022
Revenue	$	1,528		$	1,051
Loss from operations	$	(6,578	)	$	(10,328	)
Net loss	$	(19,847	)	$	(10,314	)

- Definition

Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-9

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 5: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (aa)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 7: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (aaa)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 10: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 11: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 12: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

+ Details

- Definition

Tabular disclosure of the significant judgments and assumptions made in determining whether a variable interest (as defined) held by the entity requires the variable interest entity (VIE) (as defined) to be consolidated and (or) disclose information about its involvement with the VIE, individually or in aggregate (as applicable); the nature of restrictions, if any, on the consolidated VIE's assets and on the settlement of its liabilities reported by an entity in its statement of financial position, including the carrying amounts of such assets and liabilities; the nature of, and changes in, the risks associated with involvement in the VIE; how involvement with the VIE affects the entity's financial position, financial performance, and cash flows; the lack of recourse if creditors (or beneficial interest holders) of the consolidated VIE have no recourse to the general credit of the primary beneficiary (if applicable); the terms of arrangements, giving consideration to both explicit arrangements and implicit variable interests, if any, that could require the entity to provide financial support to the VIE, including events or circumstances that could expose the entity to a loss; the methodology used by the entity for determining whether or not it is the primary beneficiary of the variable interest entity; the significant factors considered and judgments made in determining that the power to direct the activities of a VIE that most significantly impact the VIE's economic performance are shared (as defined); the carrying amounts and classification of assets and liabilities of the VIE included in the statement of financial position; the entity's maximum exposure to loss, if any, as a result of its involvement with the VIE, including how the maximum exposure is determined and significant sources of the entity's exposure to the VIE; a comparison of the carrying amounts of the assets and liabilities and the entity's maximum exposure to loss; information about any liquidity arrangements, guarantees, and (or) other commitments by third parties that may affect the fair value or risk of the entity's variable interest in the VIE; whether or not the entity has provided financial support or other support (explicitly or implicitly) to the VIE that it was not previously contractually required to provide or whether the entity intends to provide that support, including the type and amount of the support and the primary reasons for providing the support; and supplemental information the entity determines necessary to provide.

+ References + Details

Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2024	Apr. 30, 2024
Cover [Abstract]
Entity Registrant Name	INNOVIVA, INC.
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2024
Document Transition Report	false
Securities Act File Number	000-30319
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	94-3265960
Entity Address, Address Line One	1350 Old Bayshore Highway Suite 400
Entity Address, City or Town	Burlingame
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94010
City Area Code	650
Local Phone Number	238-9600
Title of 12(b) Security	Common Stock, par value $0.01 per share
Trading Symbol	INVA
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		62,444,778
Entity Central Index Key	0001080014
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q1
Amendment Flag	false

Equity and Other Investments and Fair Value Measurements - (Additional Information) (Details)	3 Months Ended
	Mar. 31, 2024 USD ($)
Fair Value Disclosures [Abstract]
Fair value of asset transfer between levels	$ 0

Goodwill and Intangible Assets (Additional Information) (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended
	May 31, 2023	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023	Aug. 22, 2022	Jul. 11, 2022
Goodwill [Line Items]
Goodwill		$ 17,905		$ 17,905
Amortization expense		6,440	$ 3,805
Goodwill, impairment losses		0
Collaboration agreement
Goodwill [Line Items]
Amortization expense		6,400	$ 3,800
In-process research and development
Goodwill [Line Items]
Useful life of Remaining In Process Research and Development	$ 2,600
In-process research and development \| Collaboration agreement
Goodwill [Line Items]
Amortization expense	$ 68,700	0
La Jolla Pharmaceutical Company
Goodwill [Line Items]
Goodwill					$ 6,400
Future amortization expense, remainder of 2024		19,400
Future amortization expense, 2025		25,800
Future amortization expense, 2026		25,800
Future amortization expense, 2027		25,800
Future amortization expense, 2028		25,800
Future amortization expense, thereafter		98,700
Intangible assets pertain to product rights and developed technologies		151,000
Entasis Therapeutics Holdings Inc
Goodwill [Line Items]
Goodwill						$ 11,500
Intangible assets pertain to product rights and developed technologies		106,700
Entasis Therapeutics Holdings Inc \| Collaboration agreement
Goodwill [Line Items]
Intangible assets pertain to product rights and developed technologies		35,400
Entasis Therapeutics Holdings Inc \| In-process research and development
Goodwill [Line Items]
Intangible assets pertain to product rights and developed technologies		$ 71,300

Balance Sheet Components (Additional Information) (Details) - La Jolla Pharmaceutical Company - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Inventory [Line Items]
Net fair value adjustment of inventory from acquisition	$ 16.1		$ 23.0
Amortization of fair value adjustments of Cost of products sold	$ 6.8	$ 6.8

Equity and Other Investments and Fair Value Measurements - Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($)
$ in Thousands

3 Months Ended

12 Months Ended

Mar. 31, 2024

Dec. 31, 2023

Fair Value Measurements

Contingent value rights

$ 325

$ 359

ISP Fund LP

Liabilities

Lock-up period

36 months

Contributed to partnership for investing

$ 300,000

Withdrawal from investment

Money market funds | ISP Fund LP

Assets

Total assets measured at estimated fair value

61,400

62,900

Equity investment | ISP Fund LP

Assets

Total assets measured at estimated fair value

225,700

248,500

Private Placement Positions and Convertible Notes | ISP Fund LP

Assets

Total assets measured at estimated fair value

61,600

60,600

Recurring basis

Assets

Total assets measured at estimated fair value

754,628

705,963

Recurring basis | Money market funds

Assets

Total assets measured at estimated fair value

151,836

170,706

Recurring basis | Equity investments and Money market funds | ISP Fund LP

Assets

Total assets measured at estimated fair value

287,139

^[1]

311,812

^[2]

Recurring basis | Term loan investment | Armata July 2023 Term Loan

Assets

Total assets measured at estimated fair value

27,426

27,044

Recurring basis | Term loan investment | Armata March 2024 Term Loan

Assets

Total assets measured at estimated fair value

35,479

Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1

Assets

Total assets measured at estimated fair value

482,178

503,162

Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds

Assets

Total assets measured at estimated fair value

151,836

170,706

Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and Money market funds | ISP Fund LP

Assets

Total assets measured at estimated fair value

225,521

^[1]

251,207

^[2]

Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Term loan investment | Armata July 2023 Term Loan

Assets

Total assets measured at estimated fair value

Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Term loan investment | Armata March 2024 Term Loan

Assets

Total assets measured at estimated fair value

Recurring basis | Significant Other Observable Inputs, Level 2

Assets

Total assets measured at estimated fair value

47,067

35,297

Recurring basis | Significant Other Observable Inputs, Level 2 | Money market funds

Assets

Total assets measured at estimated fair value

Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investments and Money market funds | ISP Fund LP

Assets

Total assets measured at estimated fair value

^[1]

^[2]

Recurring basis | Significant Other Observable Inputs, Level 2 | Term loan investment | Armata July 2023 Term Loan

Assets

Total assets measured at estimated fair value

Recurring basis | Significant Other Observable Inputs, Level 2 | Term loan investment | Armata March 2024 Term Loan

Assets

Total assets measured at estimated fair value

Recurring basis | Significant Unobservable Inputs, Level 3

Assets

Total assets measured at estimated fair value

225,383

167,504

Recurring basis | Significant Unobservable Inputs, Level 3 | Money market funds

Assets

Total assets measured at estimated fair value

Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and Money market funds | ISP Fund LP

Assets

Total assets measured at estimated fair value

61,618

^[1]

60,605

^[2]

Recurring basis | Significant Unobservable Inputs, Level 3 | Term loan investment | Armata July 2023 Term Loan

Assets

Total assets measured at estimated fair value

27,426

27,044

Recurring basis | Significant Unobservable Inputs, Level 3 | Term loan investment | Armata March 2024 Term Loan

Assets

Total assets measured at estimated fair value

35,479

Nonrecurring basis

Fair Value Measurements

Contingent value rights

325

359

Liabilities

Total liabilities measured at estimated fair value

435,983

427,836

Nonrecurring basis | Debt

Fair Value Measurements

2025 Notes

205,325

200,407

2028 Notes

230,333

227,070

Total fair value of debt

435,658

427,477

Nonrecurring basis | Quoted Price in Active Markets for Identical Assets, Level 1

Fair Value Measurements

Contingent value rights

Liabilities

Total liabilities measured at estimated fair value

Nonrecurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Debt

Fair Value Measurements

2025 Notes

2028 Notes

Total fair value of debt

Nonrecurring basis | Significant Other Observable Inputs, Level 2

Fair Value Measurements

Contingent value rights

Liabilities

Total liabilities measured at estimated fair value

435,658

427,477

Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt

Fair Value Measurements

2025 Notes

205,325

200,407

2028 Notes

230,333

227,070

Total fair value of debt

435,658

427,477

Nonrecurring basis | Significant Unobservable Inputs, Level 3

Fair Value Measurements

Contingent value rights

325

359

Liabilities

Total liabilities measured at estimated fair value

325

359

Nonrecurring basis | Significant Unobservable Inputs, Level 3 | Debt

Fair Value Measurements

2025 Notes

2028 Notes

Total fair value of debt

Armata | Recurring basis | Convertible debt investment

Assets

Total assets measured at estimated fair value

64,254

51,883

Armata | Recurring basis | Equity investment | Common stock

Assets

Total assets measured at estimated fair value

104,821

81,249

Armata | Recurring basis | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

47,067

35,297

Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Convertible debt investment

Assets

Total assets measured at estimated fair value

Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock

Assets

Total assets measured at estimated fair value

104,821

81,249

Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Convertible debt investment

Assets

Total assets measured at estimated fair value

Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Common stock

Assets

Total assets measured at estimated fair value

Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

47,067

35,297

Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible debt investment

Assets

Total assets measured at estimated fair value

64,254

51,883

Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Common stock

Assets

Total assets measured at estimated fair value

Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

InCarda | Recurring basis | Convertible debt investment

Assets

Total assets measured at estimated fair value

436

InCarda | Recurring basis | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

InCarda | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Convertible debt investment

Assets

Total assets measured at estimated fair value

InCarda | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

InCarda | Recurring basis | Significant Other Observable Inputs, Level 2 | Convertible debt investment

Assets

Total assets measured at estimated fair value

InCarda | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible debt investment

Assets

Total assets measured at estimated fair value

436

InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants

Assets

Total assets measured at estimated fair value

ImaginAb | Recurring basis | Convertible debt investment

Assets

Total assets measured at estimated fair value

2,894

ImaginAb | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Convertible debt investment

Assets

Total assets measured at estimated fair value

ImaginAb | Recurring basis | Significant Other Observable Inputs, Level 2 | Convertible debt investment

Assets

Total assets measured at estimated fair value

ImaginAb | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible debt investment

Assets

Total assets measured at estimated fair value

2,894

Gate Neuroscience [Member] | Recurring basis | Convertible debt investment

Assets

Total assets measured at estimated fair value

33,201

27,972

Gate Neuroscience [Member] | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Convertible debt investment

Assets

Total assets measured at estimated fair value

Gate Neuroscience [Member] | Recurring basis | Significant Other Observable Inputs, Level 2 | Convertible debt investment

Assets

Total assets measured at estimated fair value

Gate Neuroscience [Member] | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible debt investment

Assets

Total assets measured at estimated fair value

$ 33,201

$ 27,972

[1]

[2]

Equity and Other Investments and Fair Value Measurements - Convertible Promissory Note in Gate Neuroscience (Details) - USD ($) $ in Thousands					3 Months Ended
	Feb. 13, 2024	Oct. 06, 2023	Feb. 02, 2023	Nov. 24, 2021	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Equity Investment
Additional cash investment					$ 0	$ 35,689
Gate Neuroscience [Member]
Equity Investment
Number of common stock issued description				The number of common stock shares to be issued in a qualified event shall be equal to the amount due on the conversion date divided by the lesser of a capped conversion price (the “Capped Conversion Price”) and the qualified event price (the “Qualified Event Price”). The Capped Conversion Price is calculated as $50.0 million divided by the number of shares of common stock outstanding at such time on a fully diluted basis. The Qualified Event Price is the price per share determined by the qualified event. A qualified financing is a sale or series of sales of preferred stock where (i) at least 50 percent of counterparties are not existing shareholders, (ii) net proceeds to Gate are at least $35.0 million, and (iii) the stated or implied equity valuation of Gate is at least $80.0 million.
Additional cash investment	$ 5,000	$ 5,000	$ 5,000
Equity and long-term investments at fair value					33,200		$ 28,000
Unrealized loss from fair value changes in equity investments					$ 600	$ 700
Convertible Promissory Note Purchase Agreement \| Gate Neuroscience [Member]
Equity Investment
Convertible notes Face Value		27,700	21,500	$ 15,000
Debt instrument principal amount				$ 15,000
Debt Instrument, Interest Rate, Effective Percentage				8.00%
Note Amendment Agreement \| Gate Neuroscience [Member]
Equity Investment
Convertible notes Face Value			$ 21,500
Second Note Amendment Agreement \| Gate Neuroscience [Member]
Equity Investment
Convertible notes Face Value		$ 27,700
Third Note Amendment Agreement \| Gate Neuroscience [Member]
Equity Investment
Convertible notes Face Value	$ 33,500

Revenue Recognition (Details) - USD ($) $ in Thousands	3 Months Ended
Revenue Recognition (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Mar. 31, 2023
Disaggregation of Revenue [Line Items]
Total revenue	$ 77,499	$ 76,372
UNITED STATES \| Net Product Sales \| Geographic Concentration Risk
Disaggregation of Revenue [Line Items]
Concentration Risk, Percentage	91.00%	99.00%
GIAPREZA
Disaggregation of Revenue [Line Items]
Total revenue	$ 12,100	$ 9,000
XERAVA
Disaggregation of Revenue [Line Items]
Total revenue	4,800	2,500
XACDURO
Disaggregation of Revenue [Line Items]
Total revenue	2,200
La Jolla [Member]
Disaggregation of Revenue [Line Items]
Total revenue	$ 19,100	$ 11,500

Goodwill and Intangible Assets - Summary of Accumulated Amortization of Recognized Intangible Assets (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Finite-Lived Intangible Assets [Line Items]
Marketed products, Useful Life	10 years	10 years
Marketed products, gross carrying amount	$ 219,700	$ 219,700
In-process research and development, gross carrying amount	2,600	2,600
Collaboration agreement, gross carrying amount	35,400	35,400
Total gross carrying amount	257,700	257,700
Marketed products, Accumulated amortization	(30,763)	(25,204)
In-process research and development, accumulated amortization	0	0
Collaboration agreement, accumulated amortization	(3,042)	(2,161)
Accumulated amortization	(33,805)	(27,365)
Marketed products, net carrying amount	188,937	194,496
In-process research and development, net carrying amount	2,600	2,600
Collaboration agreement, net carrying amount	32,358	33,239
Net carrying amount	$ 223,895	$ 230,335
Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Marketed products, Useful Life	10 years	10 years
Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Marketed products, Useful Life	8 years	8 years

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Current assets:
Cash and cash equivalents	$ 178,357	$ 193,513
Accounts receivable	14,139	14,454
Receivables from collaboration arrangement	61,871	69,621
Inventory	37,437	40,737
Prepaid expenses	16,551	21,630
Other current assets	2,987	4,264
Total current assets	311,342	344,219
Property and equipment, net	324	483
Equity method investments	151,888	116,546
Equity and long-term investments	476,549	444,432
Capitalized fees paid, net	80,328	83,784
Right-of-use assets	2,269	2,536
Goodwill	17,905	17,905
Intangible assets	223,895	230,335
Other assets	3,112	3,267
Total assets	1,267,612	1,243,507
Current liabilities:
Accounts payable	890	6,717
Accrued personnel-related expenses	3,422	7,020
Accrued interest payable	833	3,422
Deferred revenue	987	1,277
Other accrued liabilities	23,747	19,698
Total current liabilities	29,879	38,134
Long-term debt, net of discount and issuance costs	446,759	446,234
Other long-term liabilities	71,686	71,870
Deferred tax liabilities, net	3,807	563
Income tax payable, long-term	11,800	11,751
Commitments and contingencies (Note 12)
Stockholders' equity:
Preferred stock: $0.01 par value, 230 shares authorized, no shares issued and outstanding	0	0
Common stock: $0.01 par value, 200,000 shares authorized, 62,797 and 63,307 issued and outstanding as of March 31, 2024 and December 31, 2023, respectively	628	633
Treasury stock: at cost, 32,005 shares as of March 31, 2024 and December 31, 2023	(393,829)	(393,829)
Additional paid-in capital	1,085,539	1,093,340
Retained earnings (accumulated deficit)	11,343	(25,189)
Total stockholders' equity	703,681	674,955
Total liabilities and stockholders' equity	$ 1,267,612	$ 1,243,507