SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(B) OR (G) OF THE SECURITIES EXCHANGE ACT OF 1934 ADVANCED MEDICINE, INC. (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER) Delaware 94-3265960 (STATE OF (I.R.S. EMPLOYER INCORPORATION OR ORGANIZATION) IDENTIFICATION NUMBER) 901 Gateway Boulevard South San Francisco, California 94080 (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES) (ZIP CODE) If this form relates to the registration of a class of If this form relates to the registration of a class securities pursuant to Section 12(b) of the Exchange of securities pursuant to Section 12(g) of the Act and is effective pursuant to General Instruction Exchange Act and is effective pursuant to General A.(c), please check the following box. / / Instruction A.(d), please check the following box. /X/ SECURITIES ACT REGISTRATION STATEMENT FILE NUMBER TO WHICH THIS FORM RELATES: 333-32990 (IF APPLICABLE) SECURITIES TO BE REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT: TITLE OF EACH CLASS NAME OF EACH EXCHANGE ON WHICH TO BE SO REGISTERED EACH CLASS IS TO BE REGISTERED Not Applicable Not Applicable SECURITIES TO BE REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT: Common Stock, $0.01 par value (TITLE OF CLASS)

ITEM 1. DESCRIPTION OF REGISTRANT'S SECURITIES TO BE REGISTERED. Incorporated herein by reference to the Description of Capital Stock section of the Registrant's Registration Statement on Form S-1 (File No. 333-32990) (the "S-1 Registration Statement"). ITEM 2. EXHIBITS. EXHIBIT NUMBER DESCRIPTION ------ ----------- 1.1 Restated Certificate of Incorporation of the Registrant (currently in effect) (incorporated herein by reference to Exhibit 3.1 to the S-1 Registration Statement). 1.2 Amended and Restated Certificate of Incorporation of the Registrant to be filed upon closing of the offering made pursuant to the S-1 Registration Statement (incorporated by reference to Exhibit 3.2 to the S-1 Registration Statement). 1.3 Bylaws of the Registrant (currently in effect) (incorporated herein by reference to Exhibit 3.3 to the S-1 Registration Statement). 1.4 Form of Amended and Restated Bylaws of the Registrant to be effective upon the closing of the offering made pursuant to the S-1 Registration Statement (incorporated herein by reference to Exhibit 3.4 to the S-1 Registration Statement). 1.5 Specimen Certificate of the Registrant's common stock (incorporated herein by reference to Exhibit 4.1 to the S-1 Registration Statement).

SIGNATURE Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereto duly authorized. ADVANCED MEDICINE, INC. Date: April 12, 2000 By: /s/ James B. Tananbaum ---------------------------------------- James B. Tananbaum Chief Executive Officer and President

EXHIBITS EXHIBIT NUMBER DESCRIPTION ------ ----------- 1.1 Restated Certificate of Incorporation of the Registrant (currently in effect) (incorporated herein by reference to Exhibit 3.1 to the S-1 Registration Statement). 1.2 Amended and Restated Certificate of Incorporation of the Registrant to be filed upon closing of the offering made pursuant to the S-1 Registration Statement (incorporated by reference to Exhibit 3.2 to the S-1 Registration Statement). 1.3 Bylaws of the Registrant (currently in effect) (incorporated herein by reference to Exhibit 3.3 to the S-1 Registration Statement). 1.4 Form of Amended and Restated Bylaws of the Registrant to be effective upon the closing of the offering made pursuant to the S-1 Registration Statement (incorporated herein by reference to Exhibit 3.4 to the S-1 Registration Statement). 1.5 Specimen Certificate of the Registrant's common stock (incorporated herein by reference to Exhibit 4.1 to the S-1 Registration Statement).